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NCT02081443 · ClinicalTrials.gov registry record · NA
In Vitro Pharmacodynamic Effects of Cangrelor in Ticagrelor Treated Patients
A NA study, sponsored by University of Florida.
- Completed
- Registry status
- NA
- Development phase
- 60
- Enrollment target
NCT02081443: Completed NA study, sponsored by University of Florida.
NCT02081443 is a NA study that has completed, run by University of Florida. The registered enrollment target is 60 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02081443, a NA study, has completed, sponsored by University of Florida.
- COMPLETED
- Registry status
- NA
- Development phase
- 60 participants
- Enrollment target
Study Summary
Cangrelor is a potent intravenous P2Y12 receptor inhibitor with rapid onset and offset of action associated with a greater reduction in ischemic events, including stent thrombosis, in patients undergoing stent procedures who have not been pretreated with clopidogrel. In vitro investigations have shown cangrelor to be associated with more rapid, potent, and consistent platelet inhibition in patients on maintenance prasugrel therapy exposed to a re-loading dose of prasugrel. However, if cangrelor exerts similar effects in ticagrelor treated patients remain unknown. The aim of the present study is to evaluate the effects on platelet function achieved after in vitro incubation with cangrelor in patients on ticagrelor maintenance dose who receive a loading dose of ticagrelor.
Primary Outcome
PRI determined by VASP between before and after incubation with 500 nM Cangrelor in each arm of treatment
Interventions
- DRUG Ticagrelor 90mg
- DRUG Ticagrelor 180mg
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2014-04 |
| Est. Completion | 2015-10 |
| Phase | NA |
What the finished NCT02081443 record still lists
NCT02081443 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower).
The record links to 0 conditions, and to 2 interventions - of which Ticagrelor 90mg is the first listed.
NCT02081443 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02081443 about?
NCT02081443 is a clinical study titled "In Vitro Pharmacodynamic Effects of Cangrelor in Ticagrelor Treated Patients". Cangrelor is a potent intravenous P2Y12 receptor inhibitor with rapid onset and offset of action associated with a greater reduction in ischemic events, including stent thrombosis, in patients undergoing stent procedures who have not been pretreated with clopidogrel. In vitro investigations have sho...
What is the current status of trial NCT02081443?
This trial is currently completed. It is a NA study. The enrollment target is 60 participants. The study started on 2014-04. Estimated completion is 2015-10.
What interventions are being tested in trial NCT02081443?
The interventions under investigation include: Ticagrelor 90mg (DRUG), Ticagrelor 180mg (DRUG).
Who is sponsoring clinical trial NCT02081443?
This trial is sponsored by University of Florida, which has 1,106 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02081443's enrollment target sits among peer trials
60 1164th of 2000 higher than 745 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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