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NCT02058979 · ClinicalTrials.gov registry record · NA
Pharmacokinetics of Bolus Versus Continuous Cefazolin Infusion in Patients Undergoing Major Surgery
A NA study, sponsored by University of Virginia.
- Completed
- Registry status
- NA
- Development phase
- 20
- Enrollment target
NCT02058979: Completed NA study, sponsored by University of Virginia.
NCT02058979 is a NA study that has completed, run by University of Virginia. The registered enrollment target is 20 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02058979, a NA study, has completed, sponsored by University of Virginia.
- COMPLETED
- Registry status
- NA
- Development phase
- 20 participants
- Enrollment target
Study Summary
Abstract The administration of an antibiotic preoperatively is an important intervention that helps to reduce the risk of post-operative health-care associated infections (HCAI). These include urinary tract, surgical site and blood stream infection. Based on the current Surgical Infection Prevention Project, (SCIP) recommendations, the choice of the antibiotic is based on the nature and site of the surgery and the presence of a β-lactam allergy (Table 1). Currently, the antibiotic treatment for preventing surgical infections is administered as a single bolus an hour before surgery, and every four hours after the initial dose. This presents a concentration profile that has a high concentration after the bolus, but decays as the kidneys remove the antibiotics. In this present study, investigators would like to compare this traditional method of delivery to a constant infusion model that would sustain a constant level of antibiotics that is defined by the difference between the rate of infusion and rate of clearance.
Primary Outcome
Plasma concentration of antibiotics during surgery
Interventions
- DRUG BOLUS INFUSION (Ancef)
- DRUG CONTINUOUS INFUSION (Ancef)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2014-11 |
| Est. Completion | 2016-06 |
| Phase | NA |
What the finished NCT02058979 record still lists
NCT02058979 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 2 interventions - of which BOLUS INFUSION (Ancef) is the first listed.
NCT02058979 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02058979 about?
NCT02058979 is a clinical study titled "Pharmacokinetics of Bolus Versus Continuous Cefazolin Infusion in Patients Undergoing Major Surgery". Abstract The administration of an antibiotic preoperatively is an important intervention that helps to reduce the risk of post-operative health-care associated infections (HCAI). These include urinary tract, surgical site and blood stream infection. Based on the current Surgical Infection Prevention...
What is the current status of trial NCT02058979?
This trial is currently completed. It is a NA study. The enrollment target is 20 participants. The study started on 2014-11. Estimated completion is 2016-06.
What interventions are being tested in trial NCT02058979?
The interventions under investigation include: BOLUS INFUSION (Ancef) (DRUG), CONTINUOUS INFUSION (Ancef) (DRUG).
Who is sponsoring clinical trial NCT02058979?
This trial is sponsored by University of Virginia, which has 449 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02058979's enrollment target sits among peer trials
20 1768th of 2000 higher than 140 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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