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NCT02039908 · ClinicalTrials.gov registry record · Phase 4
Examining Tolerance to CNS Stimulants in ADHD
A Phase 4 study, sponsored by Florida International University.
- Completed
- Registry status
- Phase 4
- Development phase
- 267
- Enrollment target
NCT02039908: Completed Phase 4 study, sponsored by Florida International University.
NCT02039908 is a Phase 4 study that has completed, run by Florida International University. The registered enrollment target is 267 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (48% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02039908, a Phase 4 study, has completed, sponsored by Florida International University.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 267 participants
- Enrollment target
Study Summary
Although stimulant medication is a well-established treatment for ADHD, it is often necessary for doctors to increase the dose over time to maintain the benefits of the medication. While medication can be very effective for improving symptoms of ADHD during the first year of use, it has not been found to significantly improve the long term course of children with ADHD. For example, in large research studies, groups of children who take medication for ten years do not have consistently better academic grades than groups of children who never used medication (individual results will vary from child to child). In order to help children with ADHD achieve the best possible outcomes, it is important for doctors to study why this happens. One possible reason is development of tolerance to the medication. Tolerance means that a drug's effects decrease when it is taken consistently over time, so that an increased dose is needed to continue showing effects. Some doctors believe that children who take stimulant medication for ADHD develop tolerance to it which would explain why benefits may not persist over time, but no research studies have been done to measure whether this occurs. This study aims to see if children show a tolerance effect to stimulant medication and whether that tolerance can be prevented by taking short breaks from the medication called medication holidays.
Primary Outcome
Monthly evaluations of medication efficacy will be used to determine whether dose adjustments are needed due to anticipated tolerance effects.
Interventions
- DRUG Methylphenidate
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 267 participants |
| Start Date | 2013-04 |
| Est. Completion | 2020-03 |
| Phase | Phase 4 |
What the finished NCT02039908 record still lists
NCT02039908 is an interventional study that assigns participants to a tested intervention. The registered 267 participants enrollment target is mid-sized for trials with a published cap, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (48% lower).
The record links to 0 conditions, and to 1 intervention - of which Methylphenidate is the first listed.
NCT02039908 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02039908 about?
NCT02039908 is a clinical study titled "Examining Tolerance to CNS Stimulants in ADHD". Although stimulant medication is a well-established treatment for ADHD, it is often necessary for doctors to increase the dose over time to maintain the benefits of the medication. While medication can be very effective for improving symptoms of ADHD during the first year of use, it has not been fou...
What is the current status of trial NCT02039908?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 267 participants. The study started on 2013-04. Estimated completion is 2020-03.
What interventions are being tested in trial NCT02039908?
The interventions under investigation include: Methylphenidate (DRUG).
Who is sponsoring clinical trial NCT02039908?
This trial is sponsored by Florida International University, which has 89 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02039908's enrollment target sits among peer trials
267 320th of 2000 higher than 1,681 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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