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NCT02031770 · ClinicalTrials.gov registry record · NA
Metabolic Acidosis and Vascular Function in Patients With Chronic Kidney Disease
A NA study, sponsored by University of Colorado, Denver.
- Completed
- Registry status
- NA
- Development phase
- 20
- Enrollment target
NCT02031770: Completed NA study, sponsored by University of Colorado, Denver.
NCT02031770 is a NA study that has completed, run by University of Colorado, Denver. The registered enrollment target is 20 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02031770, a NA study, has completed, sponsored by University of Colorado, Denver.
- COMPLETED
- Registry status
- NA
- Development phase
- 20 participants
- Enrollment target
Study Summary
Cardiovascular disease (CVD) is the leading cause of death in patients with chronic kidney disease (CKD) and large artery damage is a major factor that contributes to death. Metabolic acidosis is a common complication of CKD resulting from an inability of the diseased kidney to excrete the daily dietary acid load and it is associated with all-cause mortality in patients with CKD. However, the effect of treatment of metabolic acidosis with oral sodium bicarbonate on endothelial dysfunction and arterial stiffness in patients with CKD has not been evaluated. The investigators propose a prospective, randomized, controlled, open-label 14-week crossover pilot study examining the effect of treatment of metabolic acidosis with oral sodium bicarbonate on vascular endothelial function in 20 patients with CKD stage IV with metabolic acidosis.
Primary Outcome
The primary endpoint is change in brachial artery FMD between treatment and control conditions. Each treatment period is 6 weeks in duration with a 2 week washout period in between. Outcome measures will be repeated at the beginning and end of each period.
Interventions
- OTHER Control
- DRUG Sodium bicarbonate
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2014-01 |
| Est. Completion | 2016-03 |
| Phase | NA |
What the finished NCT02031770 record still lists
NCT02031770 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 2 interventions - of which Control is the first listed.
NCT02031770 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02031770 about?
NCT02031770 is a clinical study titled "Metabolic Acidosis and Vascular Function in Patients With Chronic Kidney Disease". Cardiovascular disease (CVD) is the leading cause of death in patients with chronic kidney disease (CKD) and large artery damage is a major factor that contributes to death. Metabolic acidosis is a common complication of CKD resulting from an inability of the diseased kidney to excrete the daily die...
What is the current status of trial NCT02031770?
This trial is currently completed. It is a NA study. The enrollment target is 20 participants. The study started on 2014-01. Estimated completion is 2016-03.
What interventions are being tested in trial NCT02031770?
The interventions under investigation include: Control (OTHER), Sodium bicarbonate (DRUG).
Who is sponsoring clinical trial NCT02031770?
This trial is sponsored by University of Colorado, Denver, which has 1,283 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02031770's enrollment target sits among peer trials
20 1768th of 2000 higher than 140 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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