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NCT02012777 · ClinicalTrials.gov registry record · Phase 1
Propanolol and Red Cell Adhesion Non-asthmatic Children Sickle Cell Disease
A Phase 1 study, sponsored by University of Miami.
- Terminated
- Registry status
- Phase 1
- Development phase
- 9
- Enrollment target
NCT02012777: Clinical Trial Phase 1 study, sponsored by University of Miami.
NCT02012777 is a Phase 1 study that was terminated before completion, run by University of Miami. The registered enrollment target is 9 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (85% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02012777, a Phase 1 study, was terminated before completion, sponsored by University of Miami.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 9 participants
- Enrollment target
Study Summary
Propanolol is a beta blocker which has been found to inhibit the ability of epinephrine to upregulate sickle red cell adhesion to laminin and endothelial cells in vitro. The purpose of this pilot study is to administer one dose of propanolol to children with sickle cell disease and to measure pre and post dose red cell adhesion. The hypothesis is that a single dose of propanolol will decrease red cell adhesion to laminin and endothelial cells as compared to baseline.
Primary Outcome
At study initiation 5mL of blood is drawn to evaluate for red cell adhesion (screening visit or visit 1). At the intervention visit 1-4 weeks later another 5mL of blood will be drawn and patient will have an ECG performed, followed by one dose of propanolol at the stratum that s/he is in. Vitals signs will be monitored (including blood pressure) for 4 hours after drug administration.
Interventions
- DRUG propranolol
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 9 participants |
| Start Date | 2010-06 |
| Est. Completion | 2013-04-03 |
| Phase | Phase 1 |
Why NCT02012777 stopped before completion
NCT02012777 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 9 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (85% lower).
The record links to 0 conditions, and to 1 intervention - of which propranolol is the first listed.
NCT02012777 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02012777 about?
NCT02012777 is a clinical study titled "Propanolol and Red Cell Adhesion Non-asthmatic Children Sickle Cell Disease". Propanolol is a beta blocker which has been found to inhibit the ability of epinephrine to upregulate sickle red cell adhesion to laminin and endothelial cells in vitro. The purpose of this pilot study is to administer one dose of propanolol to children with sickle cell disease and to measure pre an...
What is the current status of trial NCT02012777?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 9 participants. The study started on 2010-06. Estimated completion is 2013-04-03.
What interventions are being tested in trial NCT02012777?
The interventions under investigation include: propranolol (DRUG).
Who is sponsoring clinical trial NCT02012777?
This trial is sponsored by University of Miami, which has 721 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02012777's enrollment target sits among peer trials
9 1955th of 2000 higher than 42 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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