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NCT02003183 · ClinicalTrials.gov registry record
Traumatic Brain Injury and Risk for Chronic Traumatic Encephalopathy
A clinical trial, sponsored by University of California, Los Angeles.
- Completed
- Registry status
- 24
- Enrollment target
NCT02003183: Completed study, sponsored by University of California, Los Angeles.
NCT02003183 is a clinical trial that has completed, run by University of California, Los Angeles. The registered enrollment target is 24 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02003183 has completed, sponsored by University of California, Los Angeles.
- COMPLETED
- Registry status
- 24 participants
- Enrollment target
Study Summary
This project was designed to determine brain imaging patterns using 2-(1-{6-\[(2-fluorine 18-labeled fluoroethyl)methylamino\]-2-naphthyl}ethylidene)malononitrile (\[F-18\]FDDNP) with positron emission tomography (PET) in participants with suspected Chronic Traumatic Encephalopathy (CTE), a progressive degenerative disease of the brain found in people with a history of repetitive traumatic brain injuries (TBIs), characterized by personality, behavioral, and mood disturbances, cognitive impairment, and sometimes motor symptoms. Currently, CTE can only be definitely diagnosed from neuropathological examination of the brain after autopsy. Developing tools to assist in the detection of this condition in living individuals at risk would facilitate research focusing on discovering potential prevention and treatment strategies.
Primary Outcome
The outcome measure is a ratio of the volume (in milliliters) of 2-(1-{6-\[(2-fluorine 18-labeled fluoroethyl)methylamino\]-2-naphthyl}ethylidene)malononitrile (\[F-18\]FDDNP) bound within the region of interest (ROI) divided by the amount of \[F-18\]FDDNP in the cerebellum (reference region). Higher ratios are indicative of higher levels of tau and amyloid proteins within the ROI. The unit of measure is called the Distribution Volume Ratio (DVR).
Interventions
- RADIATION [F-18]FDDNP
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2013-03 |
| Est. Completion | 2018-12 |
What the finished NCT02003183 record still lists
NCT02003183 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 24 participants, a relatively small participant target.
The record links to 0 conditions, and to 1 intervention - of which [F-18]FDDNP is the first listed.
NCT02003183 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02003183 about?
NCT02003183 is a clinical study titled "Traumatic Brain Injury and Risk for Chronic Traumatic Encephalopathy". This project was designed to determine brain imaging patterns using 2-(1-{6-\[(2-fluorine 18-labeled fluoroethyl)methylamino\]-2-naphthyl}ethylidene)malononitrile (\[F-18\]FDDNP) with positron emission tomography (PET) in participants with suspected Chronic Traumatic Encephalopathy (CTE), a progress...
What is the current status of trial NCT02003183?
This trial is currently completed. The enrollment target is 24 participants. The study started on 2013-03. Estimated completion is 2018-12.
What interventions are being tested in trial NCT02003183?
The interventions under investigation include: [F-18]FDDNP (RADIATION).
Who is sponsoring clinical trial NCT02003183?
This trial is sponsored by University of California, Los Angeles, which has 897 total clinical trials registered on ClinicalTrials.gov.
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