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NCT01985685 · ClinicalTrials.gov registry record · Phase 2
The Effect of Thiamine vs. Placebo on VO2 in Critical Illness
A Phase 2 study, sponsored by Beth Israel Deaconess Medical Center.
- Completed
- Registry status
- Phase 2
- Development phase
- 66
- Enrollment target
NCT01985685: Completed Phase 2 study, sponsored by Beth Israel Deaconess Medical Center.
NCT01985685 is a Phase 2 study that has completed, run by Beth Israel Deaconess Medical Center. The registered enrollment target is 66 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (50% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01985685, a Phase 2 study, has completed, sponsored by Beth Israel Deaconess Medical Center.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 66 participants
- Enrollment target
Study Summary
The objective of this study is to determine the effect of thiamine therapy on oxygen consumption (VO2) in critically-ill patients. We will evaluate this by measuring VO2 before and after thiamine or placebo administration in patients admitted to the ICU and requiring mechanical ventilation. A secondary aim is to evaluate the effect of thiamine vs. placebo on the metabolic profile of the patients.
Primary Outcome
The primary outcome will be the change in VO2 over the 6 hours after administration of the study medication, adjusted for baseline VO2.
Interventions
- DRUG Thiamine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 66 participants |
| Start Date | 2013-10 |
| Est. Completion | 2016-12 |
| Phase | Phase 2 |
What the finished NCT01985685 record still lists
NCT01985685 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 66 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (50% lower).
The record links to 0 conditions, and to 1 intervention - of which Thiamine is the first listed.
NCT01985685 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01985685 about?
NCT01985685 is a clinical study titled "The Effect of Thiamine vs. Placebo on VO2 in Critical Illness". The objective of this study is to determine the effect of thiamine therapy on oxygen consumption (VO2) in critically-ill patients. We will evaluate this by measuring VO2 before and after thiamine or placebo administration in patients admitted to the ICU and requiring mechanical ventilation. A second...
What is the current status of trial NCT01985685?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 66 participants. The study started on 2013-10. Estimated completion is 2016-12.
What interventions are being tested in trial NCT01985685?
The interventions under investigation include: Thiamine (DRUG).
Who is sponsoring clinical trial NCT01985685?
This trial is sponsored by Beth Israel Deaconess Medical Center, which has 488 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01985685's enrollment target sits among peer trials
66 975th of 2000 higher than 1,014 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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