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NCT01945190 · ClinicalTrials.gov registry record · NA
Acupuncture for Inflammatory Pain and Central Sensitization - A Pilot Study
A NA study, sponsored by University of Vermont.
- Completed
- Registry status
- NA
- Development phase
- 15
- Enrollment target
NCT01945190 is a NA study that has completed, run by University of Vermont. The registered enrollment target is 15 participants.
The verdict
NCT01945190, a NA study, has completed, sponsored by University of Vermont.
- COMPLETED
- Registry status
- NA
- Development phase
- 15 participants
- Enrollment target
Study Summary
Acupuncture is used extensively by patients worldwide for a variety of illnesses. While research is beginning to show effectiveness in clinical pain, the mechanisms underlying how these effects are evoked are poorly understood. Experimental models in healthy human volunteers can more closely control the variables of acupuncture needling and begin to separate out the relative contribution of specific components of needling and needle stimulation. By examining acupuncture's effects on experimental inflammatory models with well-characterized physiologic mechanisms, hypotheses can begin to be generated regarding how acupuncture produces its clinical effects. We propose to establish a model which could be used as a template to examine the individual components contributing to acupuncture's clinical effects on inflammation and pain. We hypothesize that acupuncture will have analgesic and anti-inflammatory effects on a ultraviolet B induced cutaneous lesion as well as a model of heat pain testing which activates central sensitization. Twenty healthy human volunteers will participate in a crossover study with active acupuncture and sham acupuncture interventions. They will be tested for their minimal erythemal dose (MED) to ultraviolet B exposure. An experimental lesion at 3x MED will be administered on the lower leg. Background information will be collected which could affect individuals' sensitivity to pain such as anxiety and depression, as well as their expectations regarding acupuncture treatment. The following day they will return for the first experimental day. A measurement with Laser Doppler will quantify the inflammation in the ultraviolet B lesion. Heat pain testing will be performed using a computer controlled thermode both on and off the ultraviolet B lesion. On-lesion testing will be for heat pain threshold. Off-lesion testing will examine temporal summation of heat pain. Next, a licensed acupuncturist will perform either true electroacupuncture or sham ele
Interventions
- DEVICE Electroacupuncture
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2013-09 |
| Est. Completion | 2013-10 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01945190
The ClinicalTrials.gov registry entry for NCT01945190 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 15 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Vermont, which has 162 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Electroacupuncture is the first listed.
NCT01945190 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT01945190 about?
NCT01945190 is a clinical study titled "Acupuncture for Inflammatory Pain and Central Sensitization - A Pilot Study". Acupuncture is used extensively by patients worldwide for a variety of illnesses. While research is beginning to show effectiveness in clinical pain, the mechanisms underlying how these effects are evoked are poorly understood. Experimental models in healthy human volunteers can more closely control...
What is the current status of trial NCT01945190?
This trial is currently completed. It is a NA study. The enrollment target is 15 participants. The study started on 2013-09. Estimated completion is 2013-10.
What interventions are being tested in trial NCT01945190?
The interventions under investigation include: Electroacupuncture (DEVICE).
Who is sponsoring clinical trial NCT01945190?
This trial is sponsored by University of Vermont, which has 162 total clinical trials registered on ClinicalTrials.gov.
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