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NCT01936948 · ClinicalTrials.gov registry record · NA
Safety of Endoscopic Resection of Large Colorectal Polyps: A Randomized Trial.
A NA study, sponsored by White River Junction Veterans Affairs Medical Center.
- Completed
- Registry status
- NA
- Development phase
- 928
- Enrollment target
NCT01936948: Completed NA study, sponsored by White River Junction Veterans Affairs Medical Center.
NCT01936948 is a NA study that has completed, run by White River Junction Veterans Affairs Medical Center. The registered enrollment target is 928 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (34% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01936948, a NA study, has completed, sponsored by White River Junction Veterans Affairs Medical Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 928 participants
- Enrollment target
Study Summary
The effectiveness of colonoscopy in reducing colorectal cancer mortality relies on the detection and removal of neoplastic polyps. Because the risk of prevalent cancer and of transition to cancer increases with polyp size, effective and safe resection of large polyps is particularly important. Large polyps ≥20mm are removed by so-called endoscopic mucosal resection (EMR) using electrocautery snares. Resection of these large polyps is associated with a risk of severe complications that may require hospitalization and additional interventions. The most common risk is delayed bleeding which is observed in approximately 2-9% of patients. A recent retrospective study suggests that closure of the large mucosal defect after resection may decrease the risk of delayed bleeding. However, significant uncertainty remains about the polypectomy techniques to optimizing resection and minimizing risk. Important aspects that may affect risk include clipping of the mucosal defect and electrocautery setting.
Primary Outcome
A bleeding event that occurred within 30 days after completion of the colonoscopy with a study polyp resection and is associated with a decrease in hemoglobin by at least 2gm, hemodynamic instability, presentation to the ED, need for hospitalization, repeat colonoscopy, or other interventions.
Interventions
- PROCEDURE Clip closure
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 928 participants |
| Start Date | 2013-04 |
| Est. Completion | 2022-10 |
| Phase | NA |
What the finished NCT01936948 record still lists
NCT01936948 is an interventional study that assigns participants to a tested intervention. The registered 928 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (34% lower).
The record links to 0 conditions, and to 1 intervention - of which Clip closure is the first listed.
NCT01936948 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01936948 about?
NCT01936948 is a clinical study titled "Safety of Endoscopic Resection of Large Colorectal Polyps: A Randomized Trial.". The effectiveness of colonoscopy in reducing colorectal cancer mortality relies on the detection and removal of neoplastic polyps. Because the risk of prevalent cancer and of transition to cancer increases with polyp size, effective and safe resection of large polyps is particularly important. Large...
What is the current status of trial NCT01936948?
This trial is currently completed. It is a NA study. The enrollment target is 928 participants. The study started on 2013-04. Estimated completion is 2022-10.
What interventions are being tested in trial NCT01936948?
The interventions under investigation include: Clip closure (PROCEDURE).
Who is sponsoring clinical trial NCT01936948?
This trial is sponsored by White River Junction Veterans Affairs Medical Center, which has 15 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01936948's enrollment target sits among peer trials
928 123rd of 2000 higher than 1,878 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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