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NCT01935622 · ClinicalTrials.gov registry record · Phase 2
Safety and Efficacy of Doxycycline in Patients With Non-Ischemic Cardiomyopathy
A Phase 2 study, sponsored by Virginia Commonwealth University.
- Terminated
- Registry status
- Phase 2
- Development phase
- 10
- Enrollment target
NCT01935622: Clinical Trial Phase 2 study, sponsored by Virginia Commonwealth University.
NCT01935622 is a Phase 2 study that was terminated before completion, run by Virginia Commonwealth University. The registered enrollment target is 10 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (92% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01935622, a Phase 2 study, was terminated before completion, sponsored by Virginia Commonwealth University.
- TERMINATED
- Registry status
- Phase 2
- Development phase
- 10 participants
- Enrollment target
Study Summary
Non-ischemic cardiomyopathy and heart failure are highly influenced by the presence of systemic inflammation. Doxycycline is a FDA-approved drug to treat bacterial infections which also shows powerful anti-inflammatory effects. In this study we plan to determine the effects of Doxycycline in patients with stable heart failure and non-ischemic cardiomyopathy on peak of aerobic exercise capacity (peak V02) and ventilator efficiency measured with a cardiopulmonary test.
Primary Outcome
Interval change in peak VO2 measured at cardiopulmonary test
Interventions
- DRUG placebo
- DRUG Doxycycline
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2012-07 |
| Est. Completion | 2014-06 |
| Phase | Phase 2 |
Why NCT01935622 stopped before completion
NCT01935622 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (92% lower).
The record links to 0 conditions, and to 2 interventions - of which placebo is the first listed.
NCT01935622 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01935622 about?
NCT01935622 is a clinical study titled "Safety and Efficacy of Doxycycline in Patients With Non-Ischemic Cardiomyopathy". Non-ischemic cardiomyopathy and heart failure are highly influenced by the presence of systemic inflammation. Doxycycline is a FDA-approved drug to treat bacterial infections which also shows powerful anti-inflammatory effects. In this study we plan to determine the effects of Doxycycline in patie...
What is the current status of trial NCT01935622?
This trial is currently terminated. It is a Phase 2 study. The enrollment target is 10 participants. The study started on 2012-07. Estimated completion is 2014-06.
What interventions are being tested in trial NCT01935622?
The interventions under investigation include: placebo (DRUG), Doxycycline (DRUG).
Who is sponsoring clinical trial NCT01935622?
This trial is sponsored by Virginia Commonwealth University, which has 558 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01935622's enrollment target sits among peer trials
10 1968th of 2000 higher than 12 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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