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NCT01920906 · ClinicalTrials.gov registry record · NA
Comparative Analysis of Small and Large Plaque Psoriasis
A NA study, sponsored by Rockefeller University.
- Completed
- Registry status
- NA
- Development phase
- 13
- Enrollment target
NCT01920906: Completed NA study, sponsored by Rockefeller University.
NCT01920906 is a NA study that has completed, run by Rockefeller University. The registered enrollment target is 13 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01920906, a NA study, has completed, sponsored by Rockefeller University.
- COMPLETED
- Registry status
- NA
- Development phase
- 13 participants
- Enrollment target
Study Summary
Psoriasis is a chronic, debilitating skin disorder with an estimated prevalence of 2%. Psoriatic skin lesions start with initial pinhead-sized macules and then coalesce into plaques of varying sizes. Despite the great strides in the studies for psoriasis, it is still unclear why psoriatic skin lesions start with small macules and then spread peripherally. To study peripheral spreading of psoriasis, investigators plan to study small plaque psoriasis in comparison to large plaque psoriasis in the Korean population. Large plaque psoriasis is the most common form of psoriasis, seen in approximately 90% of all psoriasis participants. Large psoriatic plaques are \>5 cm in size and localize to the extensor aspects of the elbows, knees, scalp, and genital area. On the other hand, small plaque psoriasis is the common or typical form of psoriasis that occurs particularly in Korea and other Asian countries. Korean small plaque psoriasis, even when chronic, remains \<2 cm in size and is widely distributed on the upper trunk and proximal extremities. Investigators hypothesize that the expression of immune-related genes are different between small and large plaque psoriasis. The study of a genetically homogeneous cohort, characterized by the relatively high prevalence of small plaque psoriasis in the Korean population, may filter out spurious signals while allowing for significant associations to emerge from a relatively low number of participants. By comparing small and large plaque psoriasis, it is expected this study could lead to new understandings of the mechanisms involved in spreading of psoriatic plaques and provide new insights into psoriasis development.
Primary Outcome
The primary outcome measure is the expression of IL-17 (the pivotal immune related molecule in psoriasis pathogenesis) in lesional psoriatic skin samples collected from patients in Korea. The expression of IL-17 is measured by Reverse transcription polymerase chain reaction (RT-PCR) and normalized to the expression of housekeeping gene (human acidic ribosomal protein \[hARP\]). The unit of outcome measure is log2(IL-17 expression/hARP expression).
Interventions
- PROCEDURE Skin biopsy and blood test
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 13 participants |
| Start Date | 2014-01 |
| Est. Completion | 2015-06 |
| Phase | NA |
What the finished NCT01920906 record still lists
NCT01920906 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 13 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 1 intervention - of which Skin biopsy and blood test is the first listed.
NCT01920906 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01920906 about?
NCT01920906 is a clinical study titled "Comparative Analysis of Small and Large Plaque Psoriasis". Psoriasis is a chronic, debilitating skin disorder with an estimated prevalence of 2%. Psoriatic skin lesions start with initial pinhead-sized macules and then coalesce into plaques of varying sizes. Despite the great strides in the studies for psoriasis, it is still unclear why psoriatic skin lesio...
What is the current status of trial NCT01920906?
This trial is currently completed. It is a NA study. The enrollment target is 13 participants. The study started on 2014-01. Estimated completion is 2015-06.
What interventions are being tested in trial NCT01920906?
The interventions under investigation include: Skin biopsy and blood test (PROCEDURE).
Who is sponsoring clinical trial NCT01920906?
This trial is sponsored by Rockefeller University, which has 117 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01920906's enrollment target sits among peer trials
13 1911th of 2000 higher than 88 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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