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NCT01911195 · ClinicalTrials.gov registry record · NA
Reconstructing Consciousness and Cognition
A NA study, sponsored by University of Michigan.
- Completed
- Registry status
- NA
- Development phase
- 60
- Enrollment target
NCT01911195: Completed NA study, sponsored by University of Michigan.
NCT01911195 is a NA study that has completed, run by University of Michigan. The registered enrollment target is 60 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01911195, a NA study, has completed, sponsored by University of Michigan.
- COMPLETED
- Registry status
- NA
- Development phase
- 60 participants
- Enrollment target
Study Summary
Currently it is unknown how the human brain reorganizes its network organization to generate conscious experience and cognitive activity after a period of unconsciousness. Therefore, the purpose of this study is to assess how cognitive activity is reconstructed after general anesthesia. The investigators hypothesize that the brain's transition from unconsciousness to consciousness and full cognition is a complex process that occurs over an extended period of time. Specifically, the investigators hypothesize the following order of cognitive reconstitution: responsiveness to command, attention, complex scanning and visual tracking, working memory, and executive function. Volunteers will be healthy participants who are anesthetized with commonly used anesthetic drugs as well as a non-anesthetized group to control for circadian influences. A total of 60 subjects will be recruited for this study. All subjects (male and female) will perform basic tests for cognition on a laptop computer at 30-minute intervals during this study. The testing battery to be administered was assembled to assess multiple cognitive functions in order to determine whether and how cognitive processes return to baseline function. Electroencephalogram (measuring brain electrical activity) data will be monitored and recorded during both anesthesia and cognitive testing, for subsequent analysis. This study is significant because it could lead to a better understanding of the neural correlates of human consciousness, as well as normal and abnormal conscious state transitions (including barriers to such transitions).
Primary Outcome
Neurocognitive battery performed on computer
Interventions
- DRUG ISOFLURANE- Experimental Arm
- OTHER Control Group: Cognitive Testing
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2013-07 |
| Est. Completion | 2015-02-09 |
| Phase | NA |
What the finished NCT01911195 record still lists
NCT01911195 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower).
The record links to 0 conditions, and to 2 interventions - of which ISOFLURANE- Experimental Arm is the first listed.
NCT01911195 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01911195 about?
NCT01911195 is a clinical study titled "Reconstructing Consciousness and Cognition". Currently it is unknown how the human brain reorganizes its network organization to generate conscious experience and cognitive activity after a period of unconsciousness. Therefore, the purpose of this study is to assess how cognitive activity is reconstructed after general anesthesia. The investig...
What is the current status of trial NCT01911195?
This trial is currently completed. It is a NA study. The enrollment target is 60 participants. The study started on 2013-07. Estimated completion is 2015-02-09.
What interventions are being tested in trial NCT01911195?
The interventions under investigation include: ISOFLURANE- Experimental Arm (DRUG), Control Group: Cognitive Testing (OTHER).
Who is sponsoring clinical trial NCT01911195?
This trial is sponsored by University of Michigan, which has 1,327 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01911195's enrollment target sits among peer trials
60 1164th of 2000 higher than 745 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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