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NCT01904708 · ClinicalTrials.gov registry record · NA
Moderate Intensity Exercise and Phenylketonuria
A NA study, sponsored by Oregon Health and Science University.
- Terminated
- Registry status
- NA
- Development phase
- 2
- Enrollment target
NCT01904708: Clinical Trial NA study, sponsored by Oregon Health and Science University.
NCT01904708 is a NA study that was terminated before completion, run by Oregon Health and Science University. The registered enrollment target is 2 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01904708, a NA study, was terminated before completion, sponsored by Oregon Health and Science University.
- TERMINATED
- Registry status
- NA
- Development phase
- 2 participants
- Enrollment target
Study Summary
Phenylketonuria (PKU), an inherited genetic disorder, can cause irreversible brain damage, declined executive function, and autistic tendencies unless a phenylalanine (Phe) restricted diet is consistently maintained throughout life. Promoting anabolism, the uptake of free amino acids from the extracellular space, is a key component to maintaining plasma phenylalanine concentrations within treatment range among patients with PKU. Exercise promotes muscle protein synthesis and anabolism, but the effect on blood phenylalanine concentrations in patients with PKU has not been reported. Our objective is to assess the impact of an acute bout of moderate intensity exercise on protein oxidation and plasma amino acid concentrations, as a potential adjunctive therapy for patients with PKU. The investigators hypothesize that moderate intensity exercise decreases amino acid oxidation, increases muscle protein synthesis, and promotes tissue uptake of essential amino acids, thereby lowering plasma phenylalanine concentrations in patients with Phenylketonuria.
Primary Outcome
Compare the final blood sample for phenylalanine concentration from each arm of the study.
Interventions
- OTHER Acute Moderate Intensity Exercise
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 2 participants |
| Start Date | 2013-05 |
| Est. Completion | 2014-06 |
| Phase | NA |
Why NCT01904708 stopped before completion
NCT01904708 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 2 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower).
The record links to 0 conditions, and to 1 intervention - of which Acute Moderate Intensity Exercise is the first listed.
NCT01904708 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01904708 about?
NCT01904708 is a clinical study titled "Moderate Intensity Exercise and Phenylketonuria". Phenylketonuria (PKU), an inherited genetic disorder, can cause irreversible brain damage, declined executive function, and autistic tendencies unless a phenylalanine (Phe) restricted diet is consistently maintained throughout life. Promoting anabolism, the uptake of free amino acids from the extrac...
What is the current status of trial NCT01904708?
This trial is currently terminated. It is a NA study. The enrollment target is 2 participants. The study started on 2013-05. Estimated completion is 2014-06.
What interventions are being tested in trial NCT01904708?
The interventions under investigation include: Acute Moderate Intensity Exercise (OTHER).
Who is sponsoring clinical trial NCT01904708?
This trial is sponsored by Oregon Health and Science University, which has 546 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01904708's enrollment target sits among peer trials
2 1997th of 2000 the lowest of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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