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NCT01904708 · ClinicalTrials.gov registry record · NA
Moderate Intensity Exercise and Phenylketonuria
A NA study, sponsored by Oregon Health and Science University.
- Terminated
- Registry status
- NA
- Development phase
- 2
- Enrollment target
NCT01904708 is a NA study that was terminated before completion, run by Oregon Health and Science University. The registered enrollment target is 2 participants.
The verdict
NCT01904708, a NA study, was terminated before completion, sponsored by Oregon Health and Science University.
- TERMINATED
- Registry status
- NA
- Development phase
- 2 participants
- Enrollment target
Study Summary
Phenylketonuria (PKU), an inherited genetic disorder, can cause irreversible brain damage, declined executive function, and autistic tendencies unless a phenylalanine (Phe) restricted diet is consistently maintained throughout life. Promoting anabolism, the uptake of free amino acids from the extracellular space, is a key component to maintaining plasma phenylalanine concentrations within treatment range among patients with PKU. Exercise promotes muscle protein synthesis and anabolism, but the effect on blood phenylalanine concentrations in patients with PKU has not been reported. Our objective is to assess the impact of an acute bout of moderate intensity exercise on protein oxidation and plasma amino acid concentrations, as a potential adjunctive therapy for patients with PKU. The investigators hypothesize that moderate intensity exercise decreases amino acid oxidation, increases muscle protein synthesis, and promotes tissue uptake of essential amino acids, thereby lowering plasma phenylalanine concentrations in patients with Phenylketonuria.
Interventions
- OTHER Acute Moderate Intensity Exercise
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 2 participants |
| Start Date | 2013-05 |
| Est. Completion | 2014-06 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01904708
The ClinicalTrials.gov registry entry for NCT01904708 describes a study currently listed as terminated, categorized as NA. The registered enrollment target is 2 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Oregon Health and Science University, which has 546 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Acute Moderate Intensity Exercise is the first listed.
NCT01904708 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT01904708 about?
NCT01904708 is a clinical study titled "Moderate Intensity Exercise and Phenylketonuria". Phenylketonuria (PKU), an inherited genetic disorder, can cause irreversible brain damage, declined executive function, and autistic tendencies unless a phenylalanine (Phe) restricted diet is consistently maintained throughout life. Promoting anabolism, the uptake of free amino acids from the extrac...
What is the current status of trial NCT01904708?
This trial is currently terminated. It is a NA study. The enrollment target is 2 participants. The study started on 2013-05. Estimated completion is 2014-06.
What interventions are being tested in trial NCT01904708?
The interventions under investigation include: Acute Moderate Intensity Exercise (OTHER).
Who is sponsoring clinical trial NCT01904708?
This trial is sponsored by Oregon Health and Science University, which has 546 total clinical trials registered on ClinicalTrials.gov.
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