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NCT01901354 · ClinicalTrials.gov registry record · NA
Acute Lung Injury Ventilator Evaluation (ALIVE)
A NA study, sponsored by University of Wisconsin, Madison.
- Terminated
- Registry status
- NA
- Development phase
- 4
- Enrollment target
NCT01901354: Clinical Trial NA study, sponsored by University of Wisconsin, Madison.
NCT01901354 is a NA study that was terminated before completion, run by University of Wisconsin, Madison. The registered enrollment target is 4 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01901354, a NA study, was terminated before completion, sponsored by University of Wisconsin, Madison.
- TERMINATED
- Registry status
- NA
- Development phase
- 4 participants
- Enrollment target
Study Summary
This study will compare two ventilator modes in mechanically ventilated patients with acute lung injury. Acute lung injury (ALI) is a condition in which the lungs are badly injured and are not able to absorb oxygen the way healthy lungs do. About 25% of patients who are ventilated get ALI. ALI causes 75,000 deaths in the US each year. Ventilators can be set to work in different ways, called modes. One mode, called ARDSNet, pumps a small amount of air into the patient's lungs and then most of the air is released prior to the next breath. Another mode, called Airway pressure release ventilation (APRV), keeps air in the lungs longer between breaths. Both of these modes are currently used at this hospital. The investigators think APRV may help patients with ALI, but we do not know for sure.
Primary Outcome
We will assess the impact of APRV and ARDSNet ventilator modes upon plasma expression of Interleukin-6(IL-6), a biomarker that has been shown to correlate with degree of lung inflammation. The study will be powered to detect a decrease in plasma IL-6 levels (pg/mL) from ARDSNet to APRV.
Interventions
- OTHER Low-tidal-volume ventilation
- OTHER Airway Pressure Release Ventilation (APRV)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 4 participants |
| Start Date | 2013-11 |
| Est. Completion | 2014-10 |
| Phase | NA |
Why NCT01901354 stopped before completion
NCT01901354 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 4 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower).
The record links to 0 conditions, and to 2 interventions - of which Low-tidal-volume ventilation is the first listed.
NCT01901354 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01901354 about?
NCT01901354 is a clinical study titled "Acute Lung Injury Ventilator Evaluation (ALIVE)". This study will compare two ventilator modes in mechanically ventilated patients with acute lung injury. Acute lung injury (ALI) is a condition in which the lungs are badly injured and are not able to absorb oxygen the way healthy lungs do. About 25% of patients who are ventilated get ALI. ALI caus...
What is the current status of trial NCT01901354?
This trial is currently terminated. It is a NA study. The enrollment target is 4 participants. The study started on 2013-11. Estimated completion is 2014-10.
What interventions are being tested in trial NCT01901354?
The interventions under investigation include: Low-tidal-volume ventilation (OTHER), Airway Pressure Release Ventilation (APRV) (OTHER).
Who is sponsoring clinical trial NCT01901354?
This trial is sponsored by University of Wisconsin, Madison, which has 1,039 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01901354's enrollment target sits among peer trials
4 1996th of 2000 higher than 5 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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