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NCT01880008 · ClinicalTrials.gov registry record
Evaluation of FLT PET and MRI as Imaging Biomarkers of Early Treatment Response in Patients With Glioblastoma
A clinical trial, sponsored by Washington University School of Medicine.
- Completed
- Registry status
- 5
- Enrollment target
NCT01880008: Completed study, sponsored by Washington University School of Medicine.
NCT01880008 is a clinical trial that has completed, run by Washington University School of Medicine. The registered enrollment target is 5 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01880008 has completed, sponsored by Washington University School of Medicine.
- COMPLETED
- Registry status
- 5 participants
- Enrollment target
Study Summary
Glioblastoma is the most common primary malignant neoplasm of the adult brain. Even after multimodal therapy, outcomes remain poor, with a median survival of one year. Although advanced imaging methods have been suggested as molecular markers of prognosis and therapeutic response, these methods have not been validated for clinical use. In this exploratory, imaging-based, trial, thirty patients with a pathological diagnosis of glioblastoma will be followed prospectively for two years. The study examines how PET and MR imaging signals change following administration of a standard radio-chemotherapy treatment regimen to determine whether these imaging modalities can provide early indicators of response to therapeutic intervention. The investigators hypothesize that decreases in uptake of an investigational 18F-FLT PET tracer following treatment with radiation and chemotherapy will be a reliable predictor of glioblastoma response. In a more exploratory fashion, the investigators also will identify changes in diffusion and hypoxia MR imaging that may also correlate well with treatment response.
Primary Outcome
Determines the change in FLT uptake as a result of chemotherapy/radiation therapy
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 5 participants |
| Start Date | 2008-04 |
| Est. Completion | 2012-08 |
What the finished NCT01880008 record still lists
NCT01880008 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 5 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT01880008 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01880008 about?
NCT01880008 is a clinical study titled "Evaluation of FLT PET and MRI as Imaging Biomarkers of Early Treatment Response in Patients With Glioblastoma". Glioblastoma is the most common primary malignant neoplasm of the adult brain. Even after multimodal therapy, outcomes remain poor, with a median survival of one year. Although advanced imaging methods have been suggested as molecular markers of prognosis and therapeutic response, these methods have...
What is the current status of trial NCT01880008?
This trial is currently completed. The enrollment target is 5 participants. The study started on 2008-04. Estimated completion is 2012-08.
Who is sponsoring clinical trial NCT01880008?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
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