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NCT01874886 · ClinicalTrials.gov registry record
Cannabis Effects on Brain Morphology in Aging
A clinical trial of Study Focuses on Brain Morphology and Cognition in Older Subjects, sponsored by University of California, Los Angeles.
- Completed
- Registry status
- 60
- Enrollment target
- 1
- Study location
NCT01874886: Completed study of Study Focuses on Brain Morphology and Cognition in Older Subjects, sponsored by University of California, Los Angeles.
NCT01874886 is a study of Study Focuses on Brain Morphology and Cognition in Older Subjects that has completed, run by University of California, Los Angeles. The registered enrollment target is 60 participants. The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01874886, a study of Study Focuses on Brain Morphology and Cognition in Older Subjects, has completed, sponsored by University of California, Los Angeles.
- COMPLETED
- Registry status
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
Marijuana (Cannabis sativa) is the most widely used illicit drug worldwide, with 17.4 million Americans reporting past month use in 2010 and 4.6 million meeting criteria for dependence, underscoring the public health importance of understanding the biological implications of use. How heavy cannabis use affects brain structure and cognitive performance in late life is unknown. The ongoing maturation in the adolescent brain, including the developmental circuitry underlying memory performance and executive control puts the adolescent brain at high risk for detrimental effects of heavy cannabis use. With the aging of the 'baby boomer' generation, many people who used cannabis heavily as adolescents are now entering their senior years when age-related cognitive decline may begin. Cannabis use doubled in less than a decade during the 1970's when 38% of those surveyed in the U.S. Survey on Drug Abuse reported using cannabis and 12% of those users reported using cannabis more than 20 times a month. Understanding how heavy, early cannabis use may affect neurobiological and cognitive outcomes is of high importance for this aging population, which is already at risk for memory and cognitive deficits in aging. Because cannabis use appears to have a primary effect within the hippocampus, the main structure for memory and the structure affected most by age-related memory impairments and pre-clinical Alzheimer's disease, we expect that the effects of chronic cannabis use may be greatest during aging. To our knowledge, no study has investigated the long-term effects of adolescent cannabis use on hippocampal morphology and cognitive performance in an aging population. Investigators will investigate hippocampal integrity and cognitive performance using high-resolution magnetic resonance imaging (MRI), diffusion tensor imaging (DTI) and neuropsychological testing in an aging population of subjects (55-70 years old) who used cannabis more than 20 times a month for at least a year duri
Primary Outcome
Investigators will identify sources of structural differences in aging, heavy cannabis users compared to non-users with high resolution MRI to assess subtle MTL morphology.
Conditions Studied
Study Locations (1)
California
- UCLA Semel/Resnick Neuropsychiatric Institute - Los Angeles
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2013-01 |
| Est. Completion | 2019-04 |
What the finished NCT01874886 record still lists
NCT01874886 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 60 participants, a relatively small participant target.
The record links to 1 condition, with Study Focuses on Brain Morphology and Cognition in Older Subjects appearing as the primary indexed condition, and to 0 interventions.
NCT01874886 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT01874886 about?
NCT01874886 is a clinical study titled "Cannabis Effects on Brain Morphology in Aging". Marijuana (Cannabis sativa) is the most widely used illicit drug worldwide, with 17.4 million Americans reporting past month use in 2010 and 4.6 million meeting criteria for dependence, underscoring the public health importance of understanding the biological implications of use. How heavy cannabis ...
What is the current status of trial NCT01874886?
This trial is currently completed. The enrollment target is 60 participants. The study started on 2013-01. Estimated completion is 2019-04.
What conditions does trial NCT01874886 study?
This clinical trial studies the following conditions: Study Focuses on Brain Morphology and Cognition in Older Subjects.
Who is sponsoring clinical trial NCT01874886?
This trial is sponsored by University of California, Los Angeles, which has 897 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01874886 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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