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NCT01871857 · ClinicalTrials.gov registry record · Phase 4
7% Hypertonic Saline for Acute Bronchiolitis
A Phase 4 study, sponsored by Le Bonheur Children's Hospital.
- Completed
- Registry status
- Phase 4
- Development phase
- 101
- Enrollment target
NCT01871857: Completed Phase 4 study, sponsored by Le Bonheur Children's Hospital.
NCT01871857 is a Phase 4 study that has completed, run by Le Bonheur Children's Hospital. The registered enrollment target is 101 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (81% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01871857, a Phase 4 study, has completed, sponsored by Le Bonheur Children's Hospital.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 101 participants
- Enrollment target
Study Summary
Research suggests that hypertonic saline may improve mucous flow in infants with acute bronchiolitis. Data suggest a trend favoring reduced length of hospital stay and improved pulmonary scores with increasing concentration of nebulized solution to 3% and 5% saline as compared to 0.9% saline mixed with epinephrine. To our knowledge, 7% hypertonic saline has not been previously investigated. OUr hypothesis was that 7% hypertonic saline would improve bronchiolitis severity scores and admission rate.
Primary Outcome
Bronchiolitis severity scores were recorded prior to administering aerosols, after administering the aerosol, and again once the treating clinician determined the final disposition of the patient. After a 4-h observation period, the treating clinician determined patient disposition. If admitted, the patient continued to receive aerosols containing the same designated medication every 6 h until discharge or 24 h after the admission. Bronchiolitis severity scores were obtained before and after ea
Interventions
- DRUG Hypertonic saline and epinephrine
- DRUG Normal saline and epinephrine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 101 participants |
| Start Date | 2010-11 |
| Est. Completion | 2012-08 |
| Phase | Phase 4 |
What the finished NCT01871857 record still lists
NCT01871857 is an interventional study that assigns participants to a tested intervention. The registered 101 participants enrollment target is mid-sized for trials with a published cap, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (81% lower).
The record links to 0 conditions, and to 2 interventions - of which Hypertonic saline and epinephrine is the first listed.
NCT01871857 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01871857 about?
NCT01871857 is a clinical study titled "7% Hypertonic Saline for Acute Bronchiolitis". Research suggests that hypertonic saline may improve mucous flow in infants with acute bronchiolitis. Data suggest a trend favoring reduced length of hospital stay and improved pulmonary scores with increasing concentration of nebulized solution to 3% and 5% saline as compared to 0.9% saline mixed w...
What is the current status of trial NCT01871857?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 101 participants. The study started on 2010-11. Estimated completion is 2012-08.
What interventions are being tested in trial NCT01871857?
The interventions under investigation include: Hypertonic saline and epinephrine (DRUG), Normal saline and epinephrine (DRUG).
Who is sponsoring clinical trial NCT01871857?
This trial is sponsored by Le Bonheur Children's Hospital, which has 14 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01871857's enrollment target sits among peer trials
101 766th of 2000 higher than 1,231 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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