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NCT01831739 · ClinicalTrials.gov registry record
Genomic Research in Sarcoidosis
A clinical trial, sponsored by University of Pittsburgh.
- Completed
- Registry status
- 368
- Enrollment target
NCT01831739: Completed study, sponsored by University of Pittsburgh.
NCT01831739 is a clinical trial that has completed, run by University of Pittsburgh. The registered enrollment target is 368 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01831739 has completed, sponsored by University of Pittsburgh.
- COMPLETED
- Registry status
- 368 participants
- Enrollment target
Study Summary
This project is designed to address the following hypothesis: Distinct patterns in lung microbiome are characteristic of sarcoidosis phenotypes and reflected in changes in systemic inflammatory responses as measured by peripheral changes in gene transcription. The Specific Aims are: 1. To identify peripheral blood mononuclear cell (PBMC) gene expression patterns that characterize distinct sarcoidosis phenotypes. 2. To determine whether patterns in the lung microbiome are associated with sarcoidosis severity and disease phenotypes 3. To correlate mRNA and microRNA expression patterns in sarcoidosis affected organs with changes in microbiome, clinical parameters and PBMC gene expression patterns 4. To integrate clinical, transcriptomic, and microbiome data to identify novel molecular phenotypes in sarcoidosis.
Primary Outcome
To identify peripheral blood mononuclear cell (PBMC) gene expression patterns that characterize distinct sarcoidosis phenotypes, samples will be run in batches in block designs (equal numbers of phenotypes) and batches will be analyzed independently to determine reproducibility - a subset of samples will be rerun to assure continuity and established normalization algorithms will be applied 1-3. Normalized human transcript (mRNA and microRNA) levels obtained from PBMC will be related to establish
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 368 participants |
| Start Date | 2013-05 |
| Est. Completion | 2015-09 |
What the finished NCT01831739 record still lists
NCT01831739 is an observational study that tracks outcomes without assigning an intervention. The registered 368 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 0 interventions.
NCT01831739 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01831739 about?
NCT01831739 is a clinical study titled "Genomic Research in Sarcoidosis". This project is designed to address the following hypothesis: Distinct patterns in lung microbiome are characteristic of sarcoidosis phenotypes and reflected in changes in systemic inflammatory responses as measured by peripheral changes in gene transcription. The Specific Aims are: 1. To identif...
What is the current status of trial NCT01831739?
This trial is currently completed. The enrollment target is 368 participants. The study started on 2013-05. Estimated completion is 2015-09.
Who is sponsoring clinical trial NCT01831739?
This trial is sponsored by University of Pittsburgh, which has 1,238 total clinical trials registered on ClinicalTrials.gov.
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