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NCT01817517 · ClinicalTrials.gov registry record · NA
Thalamic Deep Brain Stimulation for the Treatment of Refractory Tourette Syndrome
A NA study, sponsored by Johns Hopkins University.
- Terminated
- Registry status
- NA
- Development phase
- 2
- Enrollment target
NCT01817517: Clinical Trial NA study, sponsored by Johns Hopkins University.
NCT01817517 is a NA study that was terminated before completion, run by Johns Hopkins University. The registered enrollment target is 2 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01817517, a NA study, was terminated before completion, sponsored by Johns Hopkins University.
- TERMINATED
- Registry status
- NA
- Development phase
- 2 participants
- Enrollment target
Study Summary
This research is being performed to try to understand if the use of deep brain stimulation or DBS can treat the symptoms of Tourette syndrome that do not respond well to current medications. In order to do this the investigators will place small stimulation leads on both sides of the brain in a region (a portion of the thalamus) that may alter the abnormal activity in the brain contributing to the symptoms of Tourette syndrome. This requires two surgical procedures, and several preoperative and postoperative visits for tuning the stimulation parameters and recording stimulation effects. The FDA has not approved DBS for use in people with Tourette syndrome, and Medtronic (the manufacturer of the device) has not conducted testing for the system in Tourette syndrome. Therefore its use in this study is experimental.
Primary Outcome
Investigators will assess deep brain stimulation effects on tic frequency and severity using the change in Yale Global Tic Severity Scale (YGTSS) in this population of Tourette syndrome patients. The scales range from 0-100, higher scores indicate greater tic severity and impairment.
Interventions
- DEVICE Medtronic Activa Deep Brain Stimulation System
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 2 participants |
| Start Date | 2014-03 |
| Est. Completion | 2023-02-02 |
| Phase | NA |
Why NCT01817517 stopped before completion
NCT01817517 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 2 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower).
The record links to 0 conditions, and to 1 intervention - of which Medtronic Activa Deep Brain Stimulation System is the first listed.
NCT01817517 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01817517 about?
NCT01817517 is a clinical study titled "Thalamic Deep Brain Stimulation for the Treatment of Refractory Tourette Syndrome". This research is being performed to try to understand if the use of deep brain stimulation or DBS can treat the symptoms of Tourette syndrome that do not respond well to current medications. In order to do this the investigators will place small stimulation leads on both sides of the brain in a regi...
What is the current status of trial NCT01817517?
This trial is currently terminated. It is a NA study. The enrollment target is 2 participants. The study started on 2014-03. Estimated completion is 2023-02-02.
What interventions are being tested in trial NCT01817517?
The interventions under investigation include: Medtronic Activa Deep Brain Stimulation System (DEVICE).
Who is sponsoring clinical trial NCT01817517?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01817517's enrollment target sits among peer trials
2 1997th of 2000 the lowest of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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