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NCT01796457 · ClinicalTrials.gov registry record

HBRN: Immune Regulation and Costimulation in Natural History and Therapeutic Outcome of Chronic Hepatitis B

A clinical trial of Hepatitis B, sponsored by University of Pennsylvania.

Active
Registry status
40
Enrollment target
8
Study locations

NCT01796457: Active study of Hepatitis B, sponsored by University of Pennsylvania.

NCT01796457 is a study of Hepatitis B that is active but no longer recruiting, run by University of Pennsylvania. The registered enrollment target is 40 participants, below the 1,627-participant average among 32 other Hepatitis B trials with a reported enrollment target (98% lower). The trial reports 8 study locations across 6 states. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT01796457, a study of Hepatitis B, is active but no longer recruiting, sponsored by University of Pennsylvania.

ACTIVE NOT RECRUITING
Registry status
40 participants
Enrollment target
8
Study locations

Study Summary

This is an ancillary to the NIDDK-sponsored treatment trials titled: Combination Therapy of Pegylated Interferon Alfa-2a and Tenofovir Versus Tenofovir Monotherapy in Chronic Hepatitis B (NCT01369212) and Combination Entecavir and Peginterferon Therapy in HBeAg-Positive Immune-Tolerant Adults With Chronic Hepatitis B (NCT01369199). This study will examine the balance between immune regulatory and effector responses in hepatitis B-infected participants enrolled in the HBRN's clinical trials (NCT01369212 and NCT01369199) to define natural history and treatment outcome.

Primary Outcome

HBV-specific lymphoproliferative, IFN-gamma and IL10 responses, T cell activation and costimulatory markers ( PD1, CTLA4, CD28, CD127), FoxP3+ Treg frequency, and NK frequency and expression of activating/inhibitory receptors Dendritic cell frequency

Conditions Studied

Hepatitis B

Study Locations (8)

California

  • California Pacific Medical Center - San Francisco
  • University of California San Francisco Medical Center - San Francisco

Washington

  • Virginia Mason Medical Center - Seattle
  • Harborview Medical Center - Seattle

Massachusetts

  • Beth Israel Deaconess Medical Center - Boston

Minnesota

  • University of Minnesota - Plymouth

Virginia

  • Virginia Commonwealth University Medical Center - Richmond

Ontario

  • Toronto Western Hospital Liver Centre - Toronto

Trial Details

FieldValue
Enrollment Target 40 participants
Start Date 2013-03
Est. Completion 2026-12-01
University of Pennsylvania

1,423 total trials

What the registry record for NCT01796457 still lists

NCT01796457 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 1,627-participant average among 32 other Hepatitis B trials with a reported enrollment target (98% lower).

The record links to 1 condition, with Hepatitis B appearing as the primary indexed condition, and to 0 interventions.

NCT01796457 lists 8 locations in 6 states (California, Washington, Massachusetts).

Frequently Asked Questions

What is clinical trial NCT01796457 about?

NCT01796457 is a clinical study titled "HBRN: Immune Regulation and Costimulation in Natural History and Therapeutic Outcome of Chronic Hepatitis B". This is an ancillary to the NIDDK-sponsored treatment trials titled: Combination Therapy of Pegylated Interferon Alfa-2a and Tenofovir Versus Tenofovir Monotherapy in Chronic Hepatitis B (NCT01369212) and Combination Entecavir and Peginterferon Therapy in HBeAg-Positive Immune-Tolerant Adults With C...

What is the current status of trial NCT01796457?

This trial is currently active not recruiting. The enrollment target is 40 participants. The study started on 2013-03. Estimated completion is 2026-12-01.

What conditions does trial NCT01796457 study?

This clinical trial studies the following conditions: Hepatitis B.

Who is sponsoring clinical trial NCT01796457?

This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT01796457 being conducted?

This trial has 8 study locations across California, Massachusetts, Minnesota, Virginia, Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Hepatitis B

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT01796457's enrollment target sits among peer trials

40 22nd of 32 higher than 11 of 32 other Hepatitis B trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Hepatitis B trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Related registry views

Source: ClinicalTrials.gov NCT01796457, the US trial registry maintained by the National Library of Medicine. NCT01796457 (small enrollment · multi site footprint · active not recruiting) retrieved and formatted by PlainTrial, see methodology.