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NCT01794455 · ClinicalTrials.gov registry record · Phase 4
Effects of Cerebral Hypoperfusion and Its Reversal on Late-Life Depression
A Phase 4 study, sponsored by Vanderbilt University.
- Terminated
- Registry status
- Phase 4
- Development phase
- 1
- Enrollment target
NCT01794455: Clinical Trial Phase 4 study, sponsored by Vanderbilt University.
NCT01794455 is a Phase 4 study that was terminated before completion, run by Vanderbilt University. The registered enrollment target is 1 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (100% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01794455, a Phase 4 study, was terminated before completion, sponsored by Vanderbilt University.
- TERMINATED
- Registry status
- Phase 4
- Development phase
- 1 participants
- Enrollment target
Study Summary
This pilot proposal will test the hypothesis that altered cerebral vessel reactivity and cerebral hypoperfusion (decreased blood flow to the brain) is a core mechanism underlying the relationship between vascular disease and depression in older adults. The long-term objective of this line of research is to: A) determine the relationship between vascular reactivity, cerebral hypoperfusion and the persistence of late-life depression and B) determine if improving cerebral perfusion with angiotensin receptor blockers (ARBs) improves depression outcomes.
Primary Outcome
MRI arterial spin labeling is a noninvasive approach to measuring cerebral blood flow. This relates to the Phase 1 sertraline arm.
Interventions
- DRUG Sertraline
- DRUG Candesartan
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1 participants |
| Start Date | 2013-05 |
| Est. Completion | 2015-03 |
| Phase | Phase 4 |
Why NCT01794455 stopped before completion
NCT01794455 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 1 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (100% lower).
The record links to 0 conditions, and to 2 interventions - of which Sertraline is the first listed.
NCT01794455 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01794455 about?
NCT01794455 is a clinical study titled "Effects of Cerebral Hypoperfusion and Its Reversal on Late-Life Depression". This pilot proposal will test the hypothesis that altered cerebral vessel reactivity and cerebral hypoperfusion (decreased blood flow to the brain) is a core mechanism underlying the relationship between vascular disease and depression in older adults. The long-term objective of this line of researc...
What is the current status of trial NCT01794455?
This trial is currently terminated. It is a Phase 4 study. The enrollment target is 1 participants. The study started on 2013-05. Estimated completion is 2015-03.
What interventions are being tested in trial NCT01794455?
The interventions under investigation include: Sertraline (DRUG), Candesartan (DRUG).
Who is sponsoring clinical trial NCT01794455?
This trial is sponsored by Vanderbilt University, which has 430 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01794455's enrollment target sits among peer trials
1 2000th of 2000 the lowest of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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