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COMPLETED Phase 2

Dose-Ranging Study Of Tofacitinib In Adults With Active Ankylosing Spondylitis

NCT01786668 · View on ClinicalTrials.gov ↗

Study Summary

This is the first study of oral tofacitinib in adults with active ankylosing spondylitis. It is designed to obtain information on the efficacy and safety of 3 different doses of tofacitinib.

Conditions Studied

Interventions

  • DRUG Placebo
  • DRUG Tofacitinib 2 mg
  • DRUG Tofacitinib 5 mg
  • DRUG Tofacitinib 10 mg

Study Locations (20)

Florida

  • Arthritis & Rheumatology Associates — Clearwater
  • Millennium Research — Ormond Beach
  • Southwest Florida Clinical Research Center — Tampa

Nebraska

  • Advanced Medical Imaging (MRI center) — Lincoln
  • Arthritis Center of Nebraska (X-ray center) — Lincoln
  • Physician Research Collaboration, LLC — Lincoln

North Carolina

  • Charlotte Radiology/ Carolina Imaging Services — Ballantyne
  • Joint and Muscle Research Institute — Charlotte
  • Presbyterian Imaging — Charlotte

California

  • Desert Medical Imaging — Indian Wells
  • Desert Medical Advances — Palm Desert

Maryland

  • Klein & Associates, M.D., P.A. — Hagerstown
  • Progressive Radiology — Hagerstown

Ohio

  • Paramount Medical Research & Consulting, LLC — Middleburg Heights
  • Premier Physicians Centers — Westlake

Pennsylvania

  • Altoona Center for Clinical Research — Duncansville
  • Clinical Research Center of Reading, LLC — Wyomissing

Indiana

  • Covance Central Laboratory Services,Inc — Indianapolis

Trial Details

FieldValue
Enrollment Target 208 participants
Start Date 2013-04
Est. Completion 2015-03
Phase Phase 2

Sponsor

Pfizer

769 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT01786668

The ClinicalTrials.gov registry entry for NCT01786668 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 208 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Pfizer, which has 769 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Ankylosing Spondylitis appearing as the primary indexed condition, and to 4 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT01786668 reports 20 study locations spanning 10 distinct geographic areas — top geographies include Florida, Nebraska, North Carolina. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT01786668 about?

NCT01786668 is a clinical study titled "Dose-Ranging Study Of Tofacitinib In Adults With Active Ankylosing Spondylitis". This is the first study of oral tofacitinib in adults with active ankylosing spondylitis. It is designed to obtain information on the efficacy and safety of 3 different doses of tofacitinib.

What is the current status of trial NCT01786668?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 208 participants. The study started on 2013-04. Estimated completion is 2015-03.

What conditions does trial NCT01786668 study?

This clinical trial studies the following conditions: Ankylosing Spondylitis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT01786668?

The interventions under investigation include: Placebo (DRUG), Tofacitinib 2 mg (DRUG), Tofacitinib 5 mg (DRUG), Tofacitinib 10 mg (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT01786668?

This trial is sponsored by Pfizer, which has 769 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT01786668 being conducted?

This trial has 20 study locations across California, Florida, Indiana, Maryland, Nebraska. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial