Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT01784744 · ClinicalTrials.gov registry record
Hyperthermia and the Amelioration of Autism Symptoms
A clinical trial, sponsored by Montefiore Medical Center.
- Completed
- Registry status
- 15
- Enrollment target
NCT01784744: Completed study, sponsored by Montefiore Medical Center.
NCT01784744 is a clinical trial that has completed, run by Montefiore Medical Center. The registered enrollment target is 15 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01784744 has completed, sponsored by Montefiore Medical Center.
- COMPLETED
- Registry status
- 15 participants
- Enrollment target
Study Summary
The febrile hypothesis of Autism Spectrum Disorder (ASD) stems from the observation that clinical symptoms improve during fever. This fever induced amelioration of symptoms could be due to one of three possible causes, (1) the direct effect of temperature; (2) a resulting change in the immune inflammatory system function associated with the infection or fever; and/or (3) and increase in the functionality of a previously dysfunctional Locus Coeruleus-Noradrenerigic (LC-NA) system. Little has been done to explore the potential direct effect an increased body temperature may have on autism symptomology. Parental reports have demonstrated that during febrile episodes children with ASD have improved social cognition and language skills, and decreased disruptive behaviors. In order to further explore the direct temperature effect, further investigation is needed, which the investigators propose below. The investigators propose to complete a one year double blind crossover study with 15 children with ASD between the ages of 5 and 17 years old. Five children with ASD will complete a control protocol prior to beginning the full protocol with 10 additional ASD children. This will allow for any needed amendment of protocol parameters prior to completion of the full protocol.
Interventions
- OTHER Hydroworx Pool at 98 degrees Fahrenheit
- OTHER Hydroworx Pool at 102 degrees Fahrenheit
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2012-11 |
| Est. Completion | 2013-12 |
What the finished NCT01784744 record still lists
NCT01784744 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 15 participants, a relatively small participant target.
The record links to 0 conditions, and to 2 interventions - of which Hydroworx Pool at 98 degrees Fahrenheit is the first listed.
NCT01784744 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01784744 about?
NCT01784744 is a clinical study titled "Hyperthermia and the Amelioration of Autism Symptoms". The febrile hypothesis of Autism Spectrum Disorder (ASD) stems from the observation that clinical symptoms improve during fever. This fever induced amelioration of symptoms could be due to one of three possible causes, (1) the direct effect of temperature; (2) a resulting change in the immune inflam...
What is the current status of trial NCT01784744?
This trial is currently completed. The enrollment target is 15 participants. The study started on 2012-11. Estimated completion is 2013-12.
What interventions are being tested in trial NCT01784744?
The interventions under investigation include: Hydroworx Pool at 98 degrees Fahrenheit (OTHER), Hydroworx Pool at 102 degrees Fahrenheit (OTHER).
Who is sponsoring clinical trial NCT01784744?
This trial is sponsored by Montefiore Medical Center, which has 345 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01889381 · 15 participants · Phase 2
Human Craniomaxillofacial Allotransplantation
- NCT02530073 · 15 participants · NA
Trial of Fetoscopic Endoluminal Tracheal Occlusion (FETO) for CDH
- NCT02535936 · 15 participants · NA
Cortical Plasticity in Spastic Diplegia After Selective Dorsal Rhizotomy
- NCT02918474 · 15 participants · NA
Decision Making Tool in Supporting Decision Making in Contralateral Prophylactic Mastectomy in Patients With Newly Diagnosed Breast Cancer
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia