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NCT01781182 · ClinicalTrials.gov registry record
Infant Antibiotic Resistance and Implications for Therapeutic Decision-making
A clinical trial of Bacterial Infections and Mycoses, sponsored by University Hospitals Cleveland Medical Center.
- Completed
- Registry status
- 352
- Enrollment target
- 1
- Study location
NCT01781182: Completed study of Bacterial Infections and Mycoses, sponsored by University Hospitals Cleveland Medical Center.
NCT01781182 is a study of Bacterial Infections and Mycoses that has completed, run by University Hospitals Cleveland Medical Center. The registered enrollment target is 352 participants. The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01781182, a study of Bacterial Infections and Mycoses, has completed, sponsored by University Hospitals Cleveland Medical Center.
- COMPLETED
- Registry status
- 352 participants
- Enrollment target
- 1
- Study location
Study Summary
Escalating resistance to antibiotics among disease-causing community bacteria increasingly threatens our ability to treat patients' infections. At the level of the physician-patient encounter, incentives at the patient level often take priority to society; this is often the case with antibiotic prescribing. Each patient level antibiotic treatment decision is based on how we value potential outcomes, including short-term benefits and risks and longer-term risks, including those related to future bacterial resistance to antibiotics. Unfortunately, antibiotics are often prescribed for illnesses unlikely to have a bacterial etiology; even a very small likelihood of benefit seems to outweigh an increased risk of future antibiotic resistance. While short-term effects of antibiotics on colonization with resistant bacteria have been demonstrated, the overall implications of each treatment for future individual, family and societal-level resistance remain difficult to quantify, and are often steeply discounted or ignored during decision-making. Knowledge regarding the longer-term effects of personal and household antibiotic use could better quantify these future resistance-related risks, and help guide antibiotic decision-making for physicians and patients. Infants are born with sterile nasopharyngeal and gastrointestinal tracts and yet, during the 1st year of life, become important reservoirs of resistant organisms; this creates an opportunity to study colonization and resistance starting from a microbiological tabula rasa. In this proposal, we will use an observational cohort to following newborns' antibiotic exposure and longitudinal colonization with specific bacterial pathogens and related antibiotic resistance in the 1st year of life. Our hypothesis is that during the 1st year of life, infants with personal and household antibiotic exposure will have greater colonization with resistan organisms than infants without antibiotic exposure. This project will help us unders
Conditions Studied
Study Locations (1)
Ohio
- University Hospitals Case Medical Center - Cleveland
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 352 participants |
| Start Date | 2013-02 |
| Est. Completion | 2017-03 |
What the finished NCT01781182 record still lists
NCT01781182 is an observational study that tracks outcomes without assigning an intervention. The registered 352 participants enrollment target is mid-sized for trials with a published cap.
The record links to 1 condition, with Bacterial Infections and Mycoses appearing as the primary indexed condition, and to 0 interventions.
NCT01781182 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT01781182 about?
NCT01781182 is a clinical study titled "Infant Antibiotic Resistance and Implications for Therapeutic Decision-making". Escalating resistance to antibiotics among disease-causing community bacteria increasingly threatens our ability to treat patients' infections. At the level of the physician-patient encounter, incentives at the patient level often take priority to society; this is often the case with antibiotic pres...
What is the current status of trial NCT01781182?
This trial is currently completed. The enrollment target is 352 participants. The study started on 2013-02. Estimated completion is 2017-03.
What conditions does trial NCT01781182 study?
This clinical trial studies the following conditions: Bacterial Infections and Mycoses.
Who is sponsoring clinical trial NCT01781182?
This trial is sponsored by University Hospitals Cleveland Medical Center, which has 230 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01781182 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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