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NCT01778010 · ClinicalTrials.gov registry record · Phase 2
Modafinil for Smoked Cocaine Self-Administration
A Phase 2 study, sponsored by New York State Psychiatric Institute.
- Completed
- Registry status
- Phase 2
- Development phase
- 8
- Enrollment target
NCT01778010: Completed Phase 2 study, sponsored by New York State Psychiatric Institute.
NCT01778010 is a Phase 2 study that has completed, run by New York State Psychiatric Institute. The registered enrollment target is 8 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (94% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01778010, a Phase 2 study, has completed, sponsored by New York State Psychiatric Institute.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 8 participants
- Enrollment target
Study Summary
Modafinil has been reported to reduce cocaine use in a clinical sample of infrequent users (2 days/week), but the effects of modafinil on cocaine self-administration in the laboratory have not been studied. The present study investigated the effects of modafinil maintenance on cocaine self-administration by frequent users (4 days/week) under controlled laboratory conditions. During this 48-day double-blind, crossover design study, the effects of modafinil maintenance (0, 200, and 400mg/day) on response to smoked cocaine (0, 12, 25, and 50 mg) were examined in nontreatment seeking cocaine-dependent individuals (n = 8).
Primary Outcome
The number of purchased cocaine doses as a function of cocaine dose and modafinil maintenance condition.
Interventions
- DRUG Modafinil 0 mg
- DRUG Modafinil 200 mg
- DRUG Modafinil 400 mg
- DRUG Cocaine 0 mg
- DRUG Cocaine 12 mg
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 8 participants |
| Start Date | 2009-03 |
| Est. Completion | 2013-06 |
| Phase | Phase 2 |
What the finished NCT01778010 record still lists
NCT01778010 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 8 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (94% lower).
The record links to 0 conditions, and to 5 interventions - of which Modafinil 0 mg is the first listed.
NCT01778010 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01778010 about?
NCT01778010 is a clinical study titled "Modafinil for Smoked Cocaine Self-Administration". Modafinil has been reported to reduce cocaine use in a clinical sample of infrequent users (2 days/week), but the effects of modafinil on cocaine self-administration in the laboratory have not been studied. The present study investigated the effects of modafinil maintenance on cocaine self-administr...
What is the current status of trial NCT01778010?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 8 participants. The study started on 2009-03. Estimated completion is 2013-06.
What interventions are being tested in trial NCT01778010?
The interventions under investigation include: Modafinil 0 mg (DRUG), Modafinil 200 mg (DRUG), Modafinil 400 mg (DRUG), Cocaine 0 mg (DRUG), Cocaine 12 mg (DRUG).
Who is sponsoring clinical trial NCT01778010?
This trial is sponsored by New York State Psychiatric Institute, which has 364 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01778010's enrollment target sits among peer trials
8 1990th of 2000 higher than 5 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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