Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Phase 1/2 Study of Derazantinib (ARQ 087) in Adult Subjects With Advanced Solid Tumors With FGFR Genetic Alterations
NCT01752920 · View on ClinicalTrials.gov ↗
Study Summary
This was an open-label, Phase 1/2, dose escalation and signal finding study of derazantinib administered to patients with advanced solid tumors (Part 1; Dose Escalation/Food-effect Cohorts) or with advanced solid tumors with FGFR genetic aberrations, including iCCA with FGFR2 gene fusion (Part 2; Expanded Cohort, signal finding).
Conditions Studied
Interventions
- DRUG Derazantinib low dose range
- DRUG Derazantinib middle dose range
- DRUG Derazantinib high dose range
- DRUG Derazantinib at recommended phase 2 dose (RP2D)
Study Locations (12)
Other
- Istituto Clinico Humanitas — Milan
- Istituto Nazionale Tumori (National Cancer Institute) — Milan
- Instituto Oncologico Veneto, IRCCS — Padua
- Azienda Ospedaliero-Universitaria Pisana - U.O. Oncologia Medica 2 Univ. — Pisa
Arizona
- Scottsdale Healthcare Research Institute — Scottsdale
Georgia
- Emory University, Winship Cancer Institute — Atlanta
Michigan
- Karmanos Cancer Institute, Detroit — Detroit
Nevada
- Comprehensive Cancer Centers of Nevada — Las Vegas
New York
- Montefiore-Einstein Center for Cancer Care — The Bronx
Pennsylvania
- University of Pennsylvania Hospital — Philadelphia
Texas
- START - South Texas Accelerated Research Therapeutics, LLC — San Antonio
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 119 participants |
| Start Date | 2012-12-10 |
| Est. Completion | 2018-08-28 |
| Phase | Phase 1 |
Interested in This Trial?
Always speak with your doctor before enrolling in a clinical trial.
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01752920
The ClinicalTrials.gov registry entry for NCT01752920 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 119 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Basilea Pharmaceutica, which has 9 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Solid Tumor appearing as the primary indexed condition, and to 4 interventions — of which Derazantinib low dose range is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT01752920 reports 12 study locations spanning 9 distinct geographic areas — top geographies include Other, Arizona, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT01752920 about?
NCT01752920 is a clinical study titled "Phase 1/2 Study of Derazantinib (ARQ 087) in Adult Subjects With Advanced Solid Tumors With FGFR Genetic Alterations". This was an open-label, Phase 1/2, dose escalation and signal finding study of derazantinib administered to patients with advanced solid tumors (Part 1; Dose Escalation/Food-effect Cohorts) or with advanced solid tumors with FGFR genetic aberrations, including iCCA with FGFR2 gene fusion (Part 2; Ex...
What is the current status of trial NCT01752920?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 119 participants. The study started on 2012-12-10. Estimated completion is 2018-08-28.
What conditions does trial NCT01752920 study?
This clinical trial studies the following conditions: Solid Tumor. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT01752920?
The interventions under investigation include: Derazantinib low dose range (DRUG), Derazantinib middle dose range (DRUG), Derazantinib high dose range (DRUG), Derazantinib at recommended phase 2 dose (RP2D) (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT01752920?
This trial is sponsored by Basilea Pharmaceutica, which has 9 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT01752920 being conducted?
This trial has 12 study locations across Arizona, Georgia, Michigan, Nevada, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How Clinical Trials Work
Understand phases 1-4, trial design, randomization, and the informed consent process.
Patient Rights in Clinical Trials
Your rights as a participant: consent, withdrawal, privacy, and who to contact.
Finding the Right Clinical Trial
A practical guide to searching trials, understanding eligibility, and evaluating options.
All Guides
Browse our complete library of clinical trial educational resources.
Read our methodology — how this data is sourced, computed, and verified.