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NCT01745354 · ClinicalTrials.gov registry record · Phase 1
Immunostimulatory CpG SD-101 + RT in Recurrent/Progressive Lymphoma After Allogeneic Hematopoietic Cell Transplantation (HCT)
A Phase 1 study, sponsored by Robert Lowsky.
- Terminated
- Registry status
- Phase 1
- Development phase
- 6
- Enrollment target
NCT01745354: Clinical Trial Phase 1 study, sponsored by Robert Lowsky.
NCT01745354 is a Phase 1 study that was terminated before completion, run by Robert Lowsky. The registered enrollment target is 6 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (90% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01745354, a Phase 1 study, was terminated before completion, sponsored by Robert Lowsky.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 6 participants
- Enrollment target
Study Summary
For patients with lymphoma that recurs after chemotherapy, bone marrow transplantation using cells from a healthy donor represents potentially curative treatment. In these individuals, cure is possible because transplantation of healthy donor immune cells can fight the lymphoma in the patient. The goal of this work is to test a strategy that activates the healthy donor immune cells so that they more effectively fight lymphoma and can result in an increased cure rate for these patients. Our group has previously studied CpG, an immune activating medication, in patients with lymphoma and demonstrated modest anti-tumor responses. We now have a more potent form of CpG which we intend to test to see if it will better activate the donor immune cells and result in shrinkage of tumor throughout the entire body, not just at the injected site.
Interventions
- DRUG SD-101
- RADIATION Local Radiation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 6 participants |
| Start Date | 2012-08 |
| Est. Completion | 2014-11 |
| Phase | Phase 1 |
Why NCT01745354 stopped before completion
NCT01745354 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 6 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (90% lower).
The record links to 0 conditions, and to 2 interventions - of which SD-101 is the first listed.
NCT01745354 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01745354 about?
NCT01745354 is a clinical study titled "Immunostimulatory CpG SD-101 + RT in Recurrent/Progressive Lymphoma After Allogeneic Hematopoietic Cell Transplantation (HCT)". For patients with lymphoma that recurs after chemotherapy, bone marrow transplantation using cells from a healthy donor represents potentially curative treatment. In these individuals, cure is possible because transplantation of healthy donor immune cells can fight the lymphoma in the patient. The g...
What is the current status of trial NCT01745354?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 6 participants. The study started on 2012-08. Estimated completion is 2014-11.
What interventions are being tested in trial NCT01745354?
The interventions under investigation include: SD-101 (DRUG), Local Radiation (RADIATION).
Who is sponsoring clinical trial NCT01745354?
This trial is sponsored by Robert Lowsky, which has 6 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01745354's enrollment target sits among peer trials
6 1974th of 2000 higher than 12 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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