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NCT01742754 · ClinicalTrials.gov registry record · NA
Fecal Microbiota Transplantation for Ulcerative Colitis
A NA study, sponsored by University of Washington.
- Terminated
- Registry status
- NA
- Development phase
- 7
- Enrollment target
NCT01742754 is a NA study that was terminated before completion, run by University of Washington. The registered enrollment target is 7 participants.
The verdict
NCT01742754, a NA study, was terminated before completion, sponsored by University of Washington.
- TERMINATED
- Registry status
- NA
- Development phase
- 7 participants
- Enrollment target
Study Summary
Fecal microbiota therapy (FMT) is an emerging treatment for gastrointestinal disorders marked by an imbalance in the intestinal microbial flora (dysbiosis). It is hypothesized to work by shifting the recipient's microbiota toward a eubiotic microbial community that resists colonization by pathogenic organisms or decreases its inherent inflammatory properties. Several studies now report its efficacy in treatment of severe Clostridium difficile colitis. Preliminary studies using FMT in Ulcerative Colitis (UC) have also met with some success. This is corroborated by several lines of evidence suggesting dysbiosis plays an important role in UC pathogenesis. While a recent study using FMT in patients with irritable bowel syndrome (IBS) and constipation found transplants persist for up to 2 years, the extent to which the microbiota is alterable in UC is not known. Indeed, there may be particular genetic or immunologic factors in UC leading to selection pressure preventing a change in the microbiota. As an initial step into investigating the potential efficacy of stool transplants for Ulcerative Colitis (UC), the investigators propose to determine the feasibility and stability of transplanted microbiota in a series of 10 patients with mild to moderate UC.
Interventions
- OTHER Fecal Microbiota Transplantation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 7 participants |
| Start Date | 2012-10 |
| Est. Completion | 2013-05 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01742754
The ClinicalTrials.gov registry entry for NCT01742754 describes a study currently listed as terminated, categorized as NA. The registered enrollment target is 7 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Washington, which has 1,048 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Fecal Microbiota Transplantation is the first listed.
NCT01742754 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT01742754 about?
NCT01742754 is a clinical study titled "Fecal Microbiota Transplantation for Ulcerative Colitis". Fecal microbiota therapy (FMT) is an emerging treatment for gastrointestinal disorders marked by an imbalance in the intestinal microbial flora (dysbiosis). It is hypothesized to work by shifting the recipient's microbiota toward a eubiotic microbial community that resists colonization by pathogenic...
What is the current status of trial NCT01742754?
This trial is currently terminated. It is a NA study. The enrollment target is 7 participants. The study started on 2012-10. Estimated completion is 2013-05.
What interventions are being tested in trial NCT01742754?
The interventions under investigation include: Fecal Microbiota Transplantation (OTHER).
Who is sponsoring clinical trial NCT01742754?
This trial is sponsored by University of Washington, which has 1,048 total clinical trials registered on ClinicalTrials.gov.
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