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NCT01733030 · ClinicalTrials.gov registry record
The Effects of D-cycloserine on Stimulus Generalization of Conditioned Fear Healthy Controls.
A clinical trial, sponsored by University of Minnesota.
- Completed
- Registry status
- 56
- Enrollment target
NCT01733030: Completed study, sponsored by University of Minnesota.
NCT01733030 is a clinical trial that has completed, run by University of Minnesota. The registered enrollment target is 56 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01733030 has completed, sponsored by University of Minnesota.
- COMPLETED
- Registry status
- 56 participants
- Enrollment target
Study Summary
PROJECT SUMMARY: PTSD is a debilitating psychiatric condition precipitated by exposure to extreme, or life threatening, trauma with an estimated lifetime prevalence between 8% and 9% in U.S. adults. One core symptom of PTSD is intense psychological distress in the presence of stimuli that "resemble" one or more aspects of the trauma experience (DSM-IV). This phenomenon referred to as stimulus generalization has received surprisingly little empirical testing in the context of clinical anxiety in general, and PTSD more specifically. The current proposal represents the first effort to study the neurobiology and pharmacology of this PTSD-relevant learning phenomenon across those with and without PTSD. The objective of this particular proposal is to apply fMRI and pharmacologic methods to: 1) identify brain mechanisms associated with generalization of conditioned fear and 2) examine the pharmacologic modifiability of levels of generalization using a partial agonist at the NMDA receptor complex (D-cycloserine) shown to increase discrimination of CS+ (danger cue) and CS- (safety cue) in animal studies.
Primary Outcome
fMRI (BOLD) responses
Interventions
- DRUG Seromycin
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 56 participants |
| Start Date | 2013-01 |
| Est. Completion | 2015-10-01 |
What the finished NCT01733030 record still lists
NCT01733030 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 56 participants, a relatively small participant target.
The record links to 0 conditions, and to 1 intervention - of which Seromycin is the first listed.
NCT01733030 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01733030 about?
NCT01733030 is a clinical study titled "The Effects of D-cycloserine on Stimulus Generalization of Conditioned Fear Healthy Controls.". PROJECT SUMMARY: PTSD is a debilitating psychiatric condition precipitated by exposure to extreme, or life threatening, trauma with an estimated lifetime prevalence between 8% and 9% in U.S. adults. One core symptom of PTSD is intense psychological distress in the presence of stimuli that "resemble...
What is the current status of trial NCT01733030?
This trial is currently completed. The enrollment target is 56 participants. The study started on 2013-01. Estimated completion is 2015-10-01.
What interventions are being tested in trial NCT01733030?
The interventions under investigation include: Seromycin (DRUG).
Who is sponsoring clinical trial NCT01733030?
This trial is sponsored by University of Minnesota, which has 966 total clinical trials registered on ClinicalTrials.gov.
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