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NCT01683279 · ClinicalTrials.gov registry record · Phase 1
A Pediatric Trial of Genetically Modified Autologous T Cells Directed Against CD19 for Relapsed CD19+ Acute Lymphoblastic Leukemia
A Phase 1 study of B-cell Leukemia, sponsored by Seattle Children's Hospital.
- Active
- Registry status
- Phase 1
- Development phase
- 6
- Enrollment target
- 1
- Study location
NCT01683279 is a Phase 1 study of B-cell Leukemia that is active but no longer recruiting, run by Seattle Children's Hospital. The registered enrollment target is 6 participants, below the 164-participant average among 3 other B-cell Leukemia trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state.
The verdict
NCT01683279, a Phase 1 study of B-cell Leukemia, is active but no longer recruiting, sponsored by Seattle Children's Hospital.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 6 participants
- Enrollment target
- 1
- Study location
Study Summary
Patients with relapsed leukemia often develop resistance to chemotherapy. For this reason, we are attempting to use a patient's own T cells, which can be genetically modified to expresses a chimeric antigen receptor(CAR). The CAR enables the T cell to recognize and kill the leukemic cells though the recognition of CD19, a protein expressed on the surface of the majority of pediatric ALL. This is a phase I study designed to determine the maximum tolerated dose of the CAR+ T cells and define the toxicity of the treatment. As a secondary aim, we will be looking at the efficacy of the T cells on eradicating the patient's leukemic cells.
Conditions Studied
Interventions
- BIOLOGICAL Autologous CD19 CAR+ EGFTt + T cells
Study Locations (1)
Washington
- Seattle Children's Hospital - Seattle
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 6 participants |
| Start Date | 2012-03-25 |
| Est. Completion | 2030-01-07 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01683279
The ClinicalTrials.gov registry entry for NCT01683279 describes a study currently listed as active not recruiting, categorized as Phase 1. The registered enrollment target is 6 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 164-participant average among 3 other B-cell Leukemia trials with a reported enrollment target (96% lower). The listed sponsor is Seattle Children's Hospital, which has 168 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with B-cell Leukemia appearing as the primary indexed condition, and to 1 intervention - of which Autologous CD19 CAR+ EGFTt + T cells is the first listed.
NCT01683279 reports 1 study location spanning 1 distinct geographic area - top geographies include Washington.
Frequently Asked Questions
What is clinical trial NCT01683279 about?
NCT01683279 is a clinical study titled "A Pediatric Trial of Genetically Modified Autologous T Cells Directed Against CD19 for Relapsed CD19+ Acute Lymphoblastic Leukemia". Patients with relapsed leukemia often develop resistance to chemotherapy. For this reason, we are attempting to use a patient's own T cells, which can be genetically modified to expresses a chimeric antigen receptor(CAR). The CAR enables the T cell to recognize and kill the leukemic cells though the...
What is the current status of trial NCT01683279?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 6 participants. The study started on 2012-03-25. Estimated completion is 2030-01-07.
What conditions does trial NCT01683279 study?
This clinical trial studies the following conditions: B-cell Leukemia.
What interventions are being tested in trial NCT01683279?
The interventions under investigation include: Autologous CD19 CAR+ EGFTt + T cells (BIOLOGICAL).
Who is sponsoring clinical trial NCT01683279?
This trial is sponsored by Seattle Children's Hospital, which has 168 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01683279 being conducted?
This trial has 1 study location across Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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