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NCT01668576 · ClinicalTrials.gov registry record
Properties of Mesenchymal Stem Cells in Lung Transplant
A clinical trial, sponsored by Emory University.
- Terminated
- Registry status
- 4
- Enrollment target
NCT01668576: Clinical Trial study, sponsored by Emory University.
NCT01668576 is a clinical trial that was terminated before completion, run by Emory University. The registered enrollment target is 4 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01668576 was terminated before completion, sponsored by Emory University.
- TERMINATED
- Registry status
- 4 participants
- Enrollment target
Study Summary
The major limitation to long term survival in lung transplant recipients is the development of graft failure over time, termed bronchiolitis obliterans. The conventional therapies used to prevent rejection are not effective in preventing bronchiolitis obliterans. Therefore, new therapies are needed to address this problem. A growing body of research has focused on a unique population of bone marrow cells termed Mesenchymal Stem Cells (MSCs) to improve a range of medical conditions including heart failure, autoimmune disease, and inflammatory bowel disease. MSCs can prevent animal models of bronchiolitis obliterans. Because of this information, it is plausible that MSCs could help patients as a potential treatment in lung transplantation. This proposal will test the immunologic properties of MSCs generated from such individuals to answer the question of whether generation of whether it would be feasible to use such cells in the future to prevent entities such as bronchiolitis obliterans. The Investigator will approach patients who are being considered for a lung transplant because of end stage lung disease. Enrolled patients will undergo a bone marrow aspiration where a small amount of fluid is removed from their pelvic bone. Cells obtained in this procedure will be expanded in the Emory/Georgia Tech Cell Lab. MSCs will be expanded in this lab using cell culture conditions which are standardly used for MSCs.
Primary Outcome
Assess for intrinsic variability of MSCs derived from individuals with end-stage lung disease across a range of ages, disease types, and comorbid conditions
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 4 participants |
| Start Date | 2012-08 |
| Est. Completion | 2014-09 |
Why NCT01668576 stopped before completion
NCT01668576 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 4 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT01668576 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01668576 about?
NCT01668576 is a clinical study titled "Properties of Mesenchymal Stem Cells in Lung Transplant". The major limitation to long term survival in lung transplant recipients is the development of graft failure over time, termed bronchiolitis obliterans. The conventional therapies used to prevent rejection are not effective in preventing bronchiolitis obliterans. Therefore, new therapies are needed ...
What is the current status of trial NCT01668576?
This trial is currently terminated. The enrollment target is 4 participants. The study started on 2012-08. Estimated completion is 2014-09.
Who is sponsoring clinical trial NCT01668576?
This trial is sponsored by Emory University, which has 1,208 total clinical trials registered on ClinicalTrials.gov.
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