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NCT01661595 · ClinicalTrials.gov registry record · NA
The Effect of Sildenafil and Tadalafil on Skeletal Muscle and Perceptual Fatigue
A NA study, sponsored by The University of Texas Medical Branch, Galveston.
- Completed
- Registry status
- NA
- Development phase
- 30
- Enrollment target
NCT01661595: Completed NA study, sponsored by The University of Texas Medical Branch, Galveston.
NCT01661595 is a NA study that has completed, run by The University of Texas Medical Branch, Galveston. The registered enrollment target is 30 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01661595, a NA study, has completed, sponsored by The University of Texas Medical Branch, Galveston.
- COMPLETED
- Registry status
- NA
- Development phase
- 30 participants
- Enrollment target
Study Summary
This study is funded by the Moody Endowment. In this project, we will investigate the potential effect of skeletal muscle nitric oxide (NO) production on skeletal muscle anabolism, muscle strength, physical function, and body composition in older individuals. Further, we will determine whether augmentation of NO-mediated signaling reduces fatigue and fatigability.
Primary Outcome
Isokinetic Fatigue Measure (knee extension) is measured on a Biodex System Pro 4 within a 75 degree range of motion. Subjects performed concentric contractions at a fixed speed of 120 degree/sec. 50 contractions were performed at 100% force, one contraction every second. Isokinetic fatigue will be measured at week 4 and week 8. Depending on grouping, the week 4 and week 8 measures may be placebo or active drug. Data will be reported as after 4 weeks of placebo or after 4 weeks of active drug. Da
Interventions
- DRUG Placebo
- DRUG Sildenafil
- DRUG tadalafil
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2012-11 |
| Est. Completion | 2015-06 |
| Phase | NA |
What the finished NCT01661595 record still lists
NCT01661595 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 3 interventions - of which Placebo is the first listed.
NCT01661595 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01661595 about?
NCT01661595 is a clinical study titled "The Effect of Sildenafil and Tadalafil on Skeletal Muscle and Perceptual Fatigue". This study is funded by the Moody Endowment. In this project, we will investigate the potential effect of skeletal muscle nitric oxide (NO) production on skeletal muscle anabolism, muscle strength, physical function, and body composition in older individuals. Further, we will determine whether augme...
What is the current status of trial NCT01661595?
This trial is currently completed. It is a NA study. The enrollment target is 30 participants. The study started on 2012-11. Estimated completion is 2015-06.
What interventions are being tested in trial NCT01661595?
The interventions under investigation include: Placebo (DRUG), Sildenafil (DRUG), tadalafil (DRUG).
Who is sponsoring clinical trial NCT01661595?
This trial is sponsored by The University of Texas Medical Branch, Galveston, which has 203 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01661595's enrollment target sits among peer trials
30 1593rd of 2000 higher than 299 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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