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NCT01572142 · ClinicalTrials.gov registry record
Decrease in Sense of Smell and Associated Cognitive Decline in Parkinson's Disease
A clinical trial, sponsored by University of Michigan.
- Completed
- Registry status
- 74
- Enrollment target
NCT01572142: Completed study, sponsored by University of Michigan.
NCT01572142 is a clinical trial that has completed, run by University of Michigan. The registered enrollment target is 74 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01572142 has completed, sponsored by University of Michigan.
- COMPLETED
- Registry status
- 74 participants
- Enrollment target
Study Summary
The overarching goal of this prospective cohort study is to test the hypotheses that greater severity of hyposmia is associated with increased risk of cognitive decline in PD and that worsening hyposmia parallels progressive cholinergic limbic denervation. To achieve the goals of this project, patients with PD without dementia or at-risk of dementia or with dementia will undergo longitudinal olfactory, cognitive and clinical testing for 2-4 years. AChE \[11C\]PMP or VAchT (vesicular acetylcholine transporter) \[F18\]-FEOBV PET will be performed both at study entry and at 2-years (± 6 months) follow-up. Brain MRI scans will also be performed at study entry and at 2-years (± 6 months) follow-up. Brain Beta-amyloid PET will be performed at study entry or at 2 years (± 6 months). Annual olfactory testing will be performed to better understand dynamic changes underlying the clinical and PET outcome measures.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 74 participants |
| Start Date | 2010-08 |
| Est. Completion | 2016-07 |
What the finished NCT01572142 record still lists
NCT01572142 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 74 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT01572142 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01572142 about?
NCT01572142 is a clinical study titled "Decrease in Sense of Smell and Associated Cognitive Decline in Parkinson's Disease". The overarching goal of this prospective cohort study is to test the hypotheses that greater severity of hyposmia is associated with increased risk of cognitive decline in PD and that worsening hyposmia parallels progressive cholinergic limbic denervation. To achieve the goals of this project, patie...
What is the current status of trial NCT01572142?
This trial is currently completed. The enrollment target is 74 participants. The study started on 2010-08. Estimated completion is 2016-07.
Who is sponsoring clinical trial NCT01572142?
This trial is sponsored by University of Michigan, which has 1,327 total clinical trials registered on ClinicalTrials.gov.
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