Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT01558817 · ClinicalTrials.gov registry record · NA
Changing the Paradigm of In-Hospital Cardiopulmonary Resuscitation
A NA study of Advanced Malignancy and Oxygen Dependent COPD, sponsored by University of Vermont.
- Completed
- Registry status
- NA
- Development phase
- 29
- Enrollment target
- 3
- Study locations
NCT01558817: Completed NA study of Advanced Malignancy and Oxygen Dependent COPD, sponsored by University of Vermont.
NCT01558817 is a NA study of Advanced Malignancy and Oxygen Dependent COPD that has completed, run by University of Vermont. The registered enrollment target is 29 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower). The trial reports 3 study locations across 3 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01558817, a NA study of Advanced Malignancy and Oxygen Dependent COPD, has completed, sponsored by University of Vermont.
- COMPLETED
- Registry status
- NA
- Development phase
- 29 participants
- Enrollment target
- 3
- Study locations
Study Summary
Outcomes after in-hospital cardiopulmonary resuscitation (CPR) are very poor, particularly in patients with oxygen dependent chronic obstructive pulmonary disease (COPD) or metastatic cancer. Recent work found that in-hospital CPR is being performed more often before death with unchanging survival and that fewer CPR survivors are being discharged home, thus suggesting that CPR is increasingly performed without benefit and that the burden of this ineffective treatment is increasing. Unlike other medical procedures, CPR has become the default provided to all patients even those with tremendously poor outcomes. It is time to change the paradigm of CPR. Through comparing an innovative "informed assent" approach toward in-hospital CPR (informing patients that their underlying chronic illness makes outcomes of CPR so poor that CPR is not performed while allowing them to disagree) versus usual care in a group of chronically ill patients with reduced life expectancy, the investigators aspire to demonstrate that CPR delivery can be reduced. And in addition that DNR status increases, while preserving patient quality of life and decreasing the burden of this ineffective treatment to both patients and families. If effective, this informed assent intervention has the potential to revolutionize how the investigators discuss CPR with the investigators chronically ill patients.
Primary Outcome
The primary outcome will be the difference in the proportion of patients in the informed assent intervention and informational brochure groups reporting preferences to be DNR (do not rescusitate).
Conditions Studied
Interventions
- BEHAVIORAL Informed Assent
- BEHAVIORAL Informational Brochure
Study Locations (3)
South Carolina
- Medical University of South Carolina - Charleston
Vermont
- University of Vermont and Fletcher Allen Health Care - Burlington
Washington
- University of Washington - Seattle
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 29 participants |
| Start Date | 2012-02 |
| Est. Completion | 2014-04 |
| Phase | NA |
What the finished NCT01558817 record still lists
NCT01558817 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 29 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower).
The record links to 2 conditions, with Advanced Malignancy appearing as the primary indexed condition, and to 2 interventions - of which Informed Assent is the first listed.
NCT01558817 reports a single indexed study location in South Carolina, Vermont, Washington.
Frequently Asked Questions
What is clinical trial NCT01558817 about?
NCT01558817 is a clinical study titled "Changing the Paradigm of In-Hospital Cardiopulmonary Resuscitation". Outcomes after in-hospital cardiopulmonary resuscitation (CPR) are very poor, particularly in patients with oxygen dependent chronic obstructive pulmonary disease (COPD) or metastatic cancer. Recent work found that in-hospital CPR is being performed more often before death with unchanging survival a...
What is the current status of trial NCT01558817?
This trial is currently completed. It is a NA study. The enrollment target is 29 participants. The study started on 2012-02. Estimated completion is 2014-04.
What conditions does trial NCT01558817 study?
This clinical trial studies the following conditions: Advanced Malignancy, Oxygen Dependent COPD.
What interventions are being tested in trial NCT01558817?
The interventions under investigation include: Informed Assent (BEHAVIORAL), Informational Brochure (BEHAVIORAL).
Who is sponsoring clinical trial NCT01558817?
This trial is sponsored by University of Vermont, which has 162 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01558817 being conducted?
This trial has 3 study locations across South Carolina, Vermont, Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Advanced Malignancy
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT01558817's enrollment target sits among peer trials
29 1702nd of 2000 higher than 297 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02429557 · 29 participants · Phase 1
Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure
- NCT02568878 · 29 participants · Phase 3
Creatine for Depressed Male and Female Methamphetamine Users
- NCT03014401 · 29 participants · NA
The Effect of Adipose-Derived Stem Cells for Knee Osteoarthritis
- NCT03128996 · 29 participants · Phase 1
Reduced Intensity Conditioning and Familial HLA-Mismatched BMT for Non-Malignant Disorders
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia