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NCT01557738 · ClinicalTrials.gov registry record · NA
Role of Flavanols in Exercise and Aging
A NA study, sponsored by University of Texas at Austin.
- Completed
- Registry status
- NA
- Development phase
- 20
- Enrollment target
NCT01557738: Completed NA study, sponsored by University of Texas at Austin.
NCT01557738 is a NA study that has completed, run by University of Texas at Austin. The registered enrollment target is 20 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01557738, a NA study, has completed, sponsored by University of Texas at Austin.
- COMPLETED
- Registry status
- NA
- Development phase
- 20 participants
- Enrollment target
Study Summary
It has well known that diets rich in fruits, vegetables and cocoa products are associated with positive health benefits and these positive effects have been shown to be due to compounds they contain called flavanols. Flavanols have been shown to exert their positive effects by indirectly increasing nitric oxide (NO) bioavailability. NO is a potent vasodilator that is believed to play a role in increasing blood flow to active muscle during exercise. This regulatory process is impaired with healthy aging. The underlying premise to this study is that if NO bioavailability can be increased following flavanol ingestion, will there be a restoration of blood flow during exercise in older individuals? Accordingly, the first part of this research project will compare the acute vascular effects of flavanol ingestion between a young and old group. The investigators have hypothesized that both groups will show an improvement in blood flow to active muscle during exercise, though the magnitude of the change will be greater in the older group. The second part of this project will look at the effects of 4 weeks of daily flavanol ingestion in the old group. The investigators hypothesize that subjects will demonstrate an improvement in blood flow to active muscle during exercise after the 4 week intervention and that the magnitude of the change will be greater than the acute effects. Findings from this proposal will provide evidence for the efficacy of flavanols to be used (as a simple and safe lifestyle intervention) to reverse or combat impaired blood flow regulation in older individuals.
Primary Outcome
Blood flow regulation to active muscles during knee extension exercise can be assessed by using ultrasound to measure blood flow in the femoral artery. This will be done before and after stimulation of the sympathetic nervous system. A baseline value will be obtained and then the measurement will be performed again 2 hours after flavanol ingestion.
Interventions
- DIETARY_SUPPLEMENT High Flavanol Trial
- DIETARY_SUPPLEMENT Low Flavanol Trial
- DIETARY_SUPPLEMENT High Flavanol Trial; long-term
- DIETARY_SUPPLEMENT Low Flavanol Trial; long-term effects
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2012-12 |
| Est. Completion | 2014-04 |
| Phase | NA |
What the finished NCT01557738 record still lists
NCT01557738 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 4 interventions - of which High Flavanol Trial is the first listed.
NCT01557738 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01557738 about?
NCT01557738 is a clinical study titled "Role of Flavanols in Exercise and Aging". It has well known that diets rich in fruits, vegetables and cocoa products are associated with positive health benefits and these positive effects have been shown to be due to compounds they contain called flavanols. Flavanols have been shown to exert their positive effects by indirectly increasing ...
What is the current status of trial NCT01557738?
This trial is currently completed. It is a NA study. The enrollment target is 20 participants. The study started on 2012-12. Estimated completion is 2014-04.
What interventions are being tested in trial NCT01557738?
The interventions under investigation include: High Flavanol Trial (DIETARY_SUPPLEMENT), Low Flavanol Trial (DIETARY_SUPPLEMENT), High Flavanol Trial; long-term (DIETARY_SUPPLEMENT), Low Flavanol Trial; long-term effects (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT01557738?
This trial is sponsored by University of Texas at Austin, which has 257 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01557738's enrollment target sits among peer trials
20 1768th of 2000 higher than 140 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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