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NCT01550432 · ClinicalTrials.gov registry record · NA
Effects of Glutathione (an Antioxidant) and N-Acetylcysteine on Inflammation
A NA study, sponsored by Stanford University.
- Completed
- Registry status
- NA
- Development phase
- 78
- Enrollment target
NCT01550432: Completed NA study, sponsored by Stanford University.
NCT01550432 is a NA study that has completed, run by Stanford University. The registered enrollment target is 78 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01550432, a NA study, has completed, sponsored by Stanford University.
- COMPLETED
- Registry status
- NA
- Development phase
- 78 participants
- Enrollment target
Study Summary
The rationale for the potential role of antioxidants in the prevention of cardiovascular diseases (CVD) remains strong despite the disappointing results of recent trials with a few select antioxidant vitamins. Glutathione (GSH) is one of the body's most powerful antioxidant agents but there is a surprising paucity of data on its use as an interventional therapy. Glutathione, when taken orally, is immediately broken down into its constituent amino acids, of which cysteine is the only one to be essential. Available cysteine is the critical determinant of intracellular GSH concentrations. N-acetyl cysteine (NAC) is an antioxidant supplement that has been used to provide a source of cysteine to replete GSH levels. By replenishing endogenous glutathione, it is possible that NAC would exert the same effect(s) as exogenous GSH. However, there is a new delivery system, liposomal GSH, which keeps glutathione intact. In this study, the investigators propose to match the cysteine content of NAC and GSH and compare the effects of these two supplements, at two different doses, on markers of inflammation and oxidative stress.
Interventions
- OTHER Placebo
- DIETARY_SUPPLEMENT Glutathione
- DIETARY_SUPPLEMENT N-Acetylcysteine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 78 participants |
| Start Date | 2011-06 |
| Est. Completion | 2012-07 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01550432
The ClinicalTrials.gov registry entry for NCT01550432 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 78 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Stanford University, which has 1,744 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 3 interventions - of which Placebo is the first listed.
NCT01550432 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT01550432 about?
NCT01550432 is a clinical study titled "Effects of Glutathione (an Antioxidant) and N-Acetylcysteine on Inflammation". The rationale for the potential role of antioxidants in the prevention of cardiovascular diseases (CVD) remains strong despite the disappointing results of recent trials with a few select antioxidant vitamins. Glutathione (GSH) is one of the body's most powerful antioxidant agents but there is a sur...
What is the current status of trial NCT01550432?
This trial is currently completed. It is a NA study. The enrollment target is 78 participants. The study started on 2011-06. Estimated completion is 2012-07.
What interventions are being tested in trial NCT01550432?
The interventions under investigation include: Placebo (OTHER), Glutathione (DIETARY_SUPPLEMENT), N-Acetylcysteine (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT01550432?
This trial is sponsored by Stanford University, which has 1,744 total clinical trials registered on ClinicalTrials.gov.
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