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NCT01548625 · ClinicalTrials.gov registry record
Cardiovascular Effects of Incremental Diesel Exhaust Inhalation in Middle-Aged Healthy GSTM1 Null Human Volunteers
A clinical trial, sponsored by Environmental Protection Agency (EPA).
- Completed
- Registry status
- 6
- Enrollment target
NCT01548625: Completed study, sponsored by Environmental Protection Agency (EPA).
NCT01548625 is a clinical trial that has completed, run by Environmental Protection Agency (EPA). The registered enrollment target is 6 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01548625 has completed, sponsored by Environmental Protection Agency (EPA).
- COMPLETED
- Registry status
- 6 participants
- Enrollment target
Study Summary
Purpose: A growing body of epidemiological data suggests an increased risk of cardiovascular events associated with air pollutants. Reactive oxygen species (ROS) have been implicated as a potential mechanism for the adverse effects of air pollutants and genetic polymorphisms of the glutathione-s-transferases (GSTs) have been shown to participate in the antioxidant defenses to air pollutants. This study examined the dose effects of diesel exhaust exposure on the cardiovascular system in healthy middle-aged subjects. Participants: Six healthy 50-75 year-old male and female subjects with GSTM1 null genotype had 3 sequential exposures to the diesel exhausts at concentrations approximately 100 µg/m3, 200 µg/m3, and 300 µg/m3 for 2 hours with a about 2 weeks of interval between exposures.
Primary Outcome
Brachial artery ultrasound was performed to measure vascular effects of DE exposure
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 6 participants |
| Start Date | 2007-07 |
| Est. Completion | 2008-11 |
What the finished NCT01548625 record still lists
NCT01548625 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 6 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT01548625 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01548625 about?
NCT01548625 is a clinical study titled "Cardiovascular Effects of Incremental Diesel Exhaust Inhalation in Middle-Aged Healthy GSTM1 Null Human Volunteers". Purpose: A growing body of epidemiological data suggests an increased risk of cardiovascular events associated with air pollutants. Reactive oxygen species (ROS) have been implicated as a potential mechanism for the adverse effects of air pollutants and genetic polymorphisms of the glutathione-s-tra...
What is the current status of trial NCT01548625?
This trial is currently completed. The enrollment target is 6 participants. The study started on 2007-07. Estimated completion is 2008-11.
Who is sponsoring clinical trial NCT01548625?
This trial is sponsored by Environmental Protection Agency (EPA), which has 9 total clinical trials registered on ClinicalTrials.gov.
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