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NCT01523769 · ClinicalTrials.gov registry record · NA
Umbilical Cord Milking on the Reduction of Red Blood Cell Transfusion Rates in Infants
A NA study, sponsored by Eastern Virginia Medical School.
- Completed
- Registry status
- NA
- Development phase
- 113
- Enrollment target
NCT01523769: Completed NA study, sponsored by Eastern Virginia Medical School.
NCT01523769 is a NA study that has completed, run by Eastern Virginia Medical School. The registered enrollment target is 113 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (92% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01523769, a NA study, has completed, sponsored by Eastern Virginia Medical School.
- COMPLETED
- Registry status
- NA
- Development phase
- 113 participants
- Enrollment target
Study Summary
Delayed cord clamp of at least 30 seconds in neonates under 37 weeks has shown that these infants have higher circulating blood volume in the first 24 hours, less need for blood transfusions, and less incidence of intraventricular hemorrhage. Delayed umbilical cord clamping has also been shown to increase the initial hematocrit and decrease the need for red blood cell (RBC) transfusions compared with no intervention in infants born between 27 and 33 weeks' gestation. However, a delay in cord clamping of 30-45 seconds may theoretically interfere with neonatal resuscitation. There have been few studies that addressed the active milking of the cord and its effect on neonatal resuscitation. Active milking of the umbilical cord towards the baby prior to clamping (rather than passive) should take less than 5 seconds to perform and should not interfere with neonatal resuscitation. Umbilical cord milking, as an alternative to delayed cord clamping, has been shown to increase the circulatory blood volume expressed as the hemoglobin value. Active milking of the cord prior to clamping, however, is not considered standard of care and only 1 Japanese randomized control study has reported that umbilical cord milking reduces the need for RBC transfusions, thus reducing the number of infants requiring a RBC transfusion as compared with control conditions. Our study aims to test the hypothesis that active milking of the umbilical cord will reduce the need for transfusion in preterm infants.
Primary Outcome
need for packed red blood cell transfusion in the first 28 days of neonatal life
Interventions
- PROCEDURE Umbilical Cord Milking
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 113 participants |
| Start Date | 2009-09 |
| Est. Completion | 2011-11 |
| Phase | NA |
What the finished NCT01523769 record still lists
NCT01523769 is an interventional study that assigns participants to a tested intervention. The registered 113 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (92% lower).
The record links to 0 conditions, and to 1 intervention - of which Umbilical Cord Milking is the first listed.
NCT01523769 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01523769 about?
NCT01523769 is a clinical study titled "Umbilical Cord Milking on the Reduction of Red Blood Cell Transfusion Rates in Infants". Delayed cord clamp of at least 30 seconds in neonates under 37 weeks has shown that these infants have higher circulating blood volume in the first 24 hours, less need for blood transfusions, and less incidence of intraventricular hemorrhage. Delayed umbilical cord clamping has also been shown to in...
What is the current status of trial NCT01523769?
This trial is currently completed. It is a NA study. The enrollment target is 113 participants. The study started on 2009-09. Estimated completion is 2011-11.
What interventions are being tested in trial NCT01523769?
The interventions under investigation include: Umbilical Cord Milking (PROCEDURE).
Who is sponsoring clinical trial NCT01523769?
This trial is sponsored by Eastern Virginia Medical School, which has 36 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01523769's enrollment target sits among peer trials
113 813th of 2000 higher than 1,188 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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