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NCT01492517 · ClinicalTrials.gov registry record · NA
Epigenetic Effects of Diesel Exhaust and Ozone Exposure
A NA study, sponsored by Environmental Protection Agency (EPA).
- Completed
- Registry status
- NA
- Development phase
- 42
- Enrollment target
NCT01492517: Completed NA study, sponsored by Environmental Protection Agency (EPA).
NCT01492517 is a NA study that has completed, run by Environmental Protection Agency (EPA). The registered enrollment target is 42 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01492517, a NA study, has completed, sponsored by Environmental Protection Agency (EPA).
- COMPLETED
- Registry status
- NA
- Development phase
- 42 participants
- Enrollment target
Study Summary
Purpose: The purpose of this protocol is to compare the genetic and epigenetic effects between diesel exhaust and ozone exposure in healthy individuals and in mild/moderate asthmatics. Participants: The investigators will recruit up to 30 mild to moderate asthmatics and up to 50 healthy adults to participate in this study. Procedures (methods): Subjects will be exposed to clean air, to 300 µg/m3 of diesel exhaust for 2 hours and to 0.3 ppm of ozone for 2 hours with intermittent exercise in a controlled environment chamber. Primary endpoints will include spirometry and lung cell changes post-exposure. Secondary endpoints will include analysis of blood clotting/coagulation factors, Holter monitoring of cardiac parameters, analysis of soluble factors present in plasma and bronchial lavage and analysis of intracellular factors present in lung tissue obtained from a brush biopsy.
Interventions
- OTHER Clean Air
- OTHER Ozone exposure
- OTHER Diesel exhaust
- OTHER Ozone18
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 42 participants |
| Start Date | 2010-05 |
| Est. Completion | 2015-05 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01492517
The ClinicalTrials.gov registry entry for NCT01492517 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 42 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Environmental Protection Agency (EPA), which has 9 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 4 interventions - of which Clean Air is the first listed.
NCT01492517 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT01492517 about?
NCT01492517 is a clinical study titled "Epigenetic Effects of Diesel Exhaust and Ozone Exposure". Purpose: The purpose of this protocol is to compare the genetic and epigenetic effects between diesel exhaust and ozone exposure in healthy individuals and in mild/moderate asthmatics. Participants: The investigators will recruit up to 30 mild to moderate asthmatics and up to 50 healthy adults to p...
What is the current status of trial NCT01492517?
This trial is currently completed. It is a NA study. The enrollment target is 42 participants. The study started on 2010-05. Estimated completion is 2015-05.
What interventions are being tested in trial NCT01492517?
The interventions under investigation include: Clean Air (OTHER), Ozone exposure (OTHER), Diesel exhaust (OTHER), Ozone18 (OTHER).
Who is sponsoring clinical trial NCT01492517?
This trial is sponsored by Environmental Protection Agency (EPA), which has 9 total clinical trials registered on ClinicalTrials.gov.
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