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NCT01486342 · ClinicalTrials.gov registry record
PET Imaging in Patients at Risk for Acute Lung Injury
A clinical trial, sponsored by Washington University School of Medicine.
- Completed
- Registry status
- 5
- Enrollment target
NCT01486342: Completed study, sponsored by Washington University School of Medicine.
NCT01486342 is a clinical trial that has completed, run by Washington University School of Medicine. The registered enrollment target is 5 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01486342 has completed, sponsored by Washington University School of Medicine.
- COMPLETED
- Registry status
- 5 participants
- Enrollment target
Study Summary
Despite decades of research, the mortality in acute lung injury remains very high and treatment options are very limited. Given these facts, the best treatment modality may be in prevention of this lethal syndrome. Historically, imaging has played a crucial role in understanding ALI. The appearance of chest radiography is one of the consensus criteria in defining ALI, and commuted tomography (CT) scans further advanced the understanding of the pathoanatomy of ALI. While valuable, these imaging modalities are nonspecific and do not incorporate functional cellular physiology. PET imaging measures concentrations of radioisotopes in the body. By embedding in, but not altering molecules, the natural fate of these tracers can be studied with PET imaging. Advances in the understanding of ALI include blood flow distribution, as well as the response to alveolar recruitment maneuvers and prone positioning. Not all patients who are receiving mechanical ventilation develop ALI. Inflammation in the lungs is known to play a key early role in the development and progression of ALI. Secondary to inflammation, the lungs develop edema and do not exchange oxygen as well. This early inflammation is in part driven by a specific type of immune cell called the neutrophil. These cells seem to travel and become sequestered in the lung- they are "recruited" to the lung during this inflammatory stage. When there, these neutrophils release inflammatory substances which are integral in the development of ALI. Neutrophils use primarily glucose as a fuel source. The radio isotope \[18F\]Fluorodeoxyglucose (FDG)is a glucose analog and therefore taken up/ingested by the neutrophils as a part of their normal metabolism. Because of this fact, positron emission tomography (PET) using the radio isotope \[18F\]FDG is a highly sensitive marker to look at the recruitment of neutrophils to the lung, therefore quantifying the degree of pulmonary inflammation prior to the development of ALI. The investiga
Primary Outcome
The influx constant describes the rate of FDG uptake and represents pulmonary inflammation
Interventions
- RADIATION PET-CT scan
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 5 participants |
| Start Date | 2011-10 |
| Est. Completion | 2012-10 |
What the finished NCT01486342 record still lists
NCT01486342 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 5 participants, a relatively small participant target.
The record links to 0 conditions, and to 1 intervention - of which PET-CT scan is the first listed.
NCT01486342 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01486342 about?
NCT01486342 is a clinical study titled "PET Imaging in Patients at Risk for Acute Lung Injury". Despite decades of research, the mortality in acute lung injury remains very high and treatment options are very limited. Given these facts, the best treatment modality may be in prevention of this lethal syndrome. Historically, imaging has played a crucial role in understanding ALI. The appearance...
What is the current status of trial NCT01486342?
This trial is currently completed. The enrollment target is 5 participants. The study started on 2011-10. Estimated completion is 2012-10.
What interventions are being tested in trial NCT01486342?
The interventions under investigation include: PET-CT scan (RADIATION).
Who is sponsoring clinical trial NCT01486342?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
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