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NCT01474915 · ClinicalTrials.gov registry record · Phase 4

Aprepitant Versus Ondansetron in Preoperative Triple-therapy Treatment of Nausea and Vomiting

A Phase 4 study of Nausea and Postoperative Nausea and Vomiting (PONV), sponsored by Sergio Bergese.

Completed
Registry status
Phase 4
Development phase
122
Enrollment target
1
Study location

NCT01474915 is a Phase 4 study of Nausea and Postoperative Nausea and Vomiting (PONV) that has completed, run by Sergio Bergese. The registered enrollment target is 122 participants, below the 237-participant average among 17 other Nausea trials with a reported enrollment target (49% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT01474915, a Phase 4 study of Nausea and Postoperative Nausea and Vomiting (PONV), has completed, sponsored by Sergio Bergese.

COMPLETED
Registry status
Phase 4
Development phase
122 participants
Enrollment target
1
Study location

Study Summary

This study is being done to determine the efficacies of two preventative drug combinations for postoperative nausea and vomiting in patients undergoing neurosurgery. The aim of this study is to compare the efficacy of using aprepitant instead of ondansetron in combination with dexamethasone and promethazine for post-operative nausea and vomiting prophylaxis. By completing this comparison study investigators will determine the most efficacious drug combination which will allow us to enhance the overall comfort and satisfaction of neurosurgical patients in the immediate postoperative period.

Conditions Studied

Nausea Postoperative Nausea and Vomiting (PONV)

Interventions

  • DRUG Dexamethasone
  • DRUG Ondansetron
  • DRUG Aprepitant
  • DRUG Promethazine

Study Locations (1)

Ohio

  • The Ohio State University Wexner Medical Center - Columbus

Trial Details

FieldValue
Enrollment Target 122 participants
Start Date 2007-06
Est. Completion 2013-04
Phase Phase 4

Sponsor

Sergio Bergese

1 total trials

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What the Registry Record Tells You About NCT01474915

The ClinicalTrials.gov registry entry for NCT01474915 describes a study currently listed as completed, categorized as Phase 4. The registered enrollment target is 122 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 237-participant average among 17 other Nausea trials with a reported enrollment target (49% lower). The listed sponsor is Sergio Bergese, which has 1 total studies on file at ClinicalTrials.gov.

The record links to 2 conditions, with Nausea appearing as the primary indexed condition, and to 4 interventions - of which Dexamethasone is the first listed.

NCT01474915 reports 1 study location spanning 1 distinct geographic area - top geographies include Ohio.

Frequently Asked Questions

What is clinical trial NCT01474915 about?

NCT01474915 is a clinical study titled "Aprepitant Versus Ondansetron in Preoperative Triple-therapy Treatment of Nausea and Vomiting". This study is being done to determine the efficacies of two preventative drug combinations for postoperative nausea and vomiting in patients undergoing neurosurgery. The aim of this study is to compare the efficacy of using aprepitant instead of ondansetron in combination with dexamethasone and prom...

What is the current status of trial NCT01474915?

This trial is currently completed. It is a Phase 4 study. The enrollment target is 122 participants. The study started on 2007-06. Estimated completion is 2013-04.

What conditions does trial NCT01474915 study?

This clinical trial studies the following conditions: Nausea, Postoperative Nausea and Vomiting (PONV).

What interventions are being tested in trial NCT01474915?

The interventions under investigation include: Dexamethasone (DRUG), Ondansetron (DRUG), Aprepitant (DRUG), Promethazine (DRUG).

Who is sponsoring clinical trial NCT01474915?

This trial is sponsored by Sergio Bergese, which has 1 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT01474915 being conducted?

This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.