Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT01458522 · ClinicalTrials.gov registry record · Phase 2
Intravenous Lacosamide Compared With Fosphenytoin in the Treatment of Patients With Frequent Nonconvulsive Seizures
A Phase 2 study of Nonconvulsive Seizures, sponsored by Aatif Husain.
- Completed
- Registry status
- Phase 2
- Development phase
- 74
- Enrollment target
- 11
- Study locations
NCT01458522: Completed Phase 2 study of Nonconvulsive Seizures, sponsored by Aatif Husain.
NCT01458522 is a Phase 2 study of Nonconvulsive Seizures that has completed, run by Aatif Husain. The registered enrollment target is 74 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (44% lower). The trial reports 11 study locations across 8 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01458522, a Phase 2 study of Nonconvulsive Seizures, has completed, sponsored by Aatif Husain.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 74 participants
- Enrollment target
- 11
- Study locations
Study Summary
This a phase 2 study comparing the efficacy of intravenous (IV) lacosamide (LCM) with IV fosphenytoin (fPHT) in controlling frequent nonconvulsive seizures (NCSs), the Adverse Events profile of LCM compared with fPHT when used to treat frequent NCSs, and length of stay in an intensive care unit for subjects treated with LCM versus subjects treated with fPHT. The trial will include a preacute-treatment period, an acute-treatment period, a postacute-treatment period, and a long-term follow-up period.
Primary Outcome
Percentage of subjects who experience no nonconvulsive seizures (NCS) for 24 hours (after the 2-hour observation-only period) following treatment with LCM vs. fPHT, as measured by continuous electroencephalography (cEEG) monitoring with blinded review.
Conditions Studied
Interventions
- DRUG fPHT
- DRUG LCM
Study Locations (11)
Massachusetts
- Massachusetts General Hospital - Boston
- Beth Israel Deaconess Medical Center - Boston
- Brigham and Woman's Hospital - Boston
North Carolina
- Mission Hospital - Asheville
- Duke University Medical Center - Durham
California
- Huntington Memorial Hospital - Pasadena
Connecticut
- Yale University School of Medicine - New Haven
Georgia
- Emory University School of Medicine - Atlanta
South Carolina
- Medical University of South Carolina - Charleston
Tennessee
- Vanderbilt University Medical Center - Nashville
Texas
- University of Texas Southwestern Medical Center Dallas - Dallas
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 74 participants |
| Start Date | 2012-05 |
| Est. Completion | 2015-07 |
| Phase | Phase 2 |
What the finished NCT01458522 record still lists
NCT01458522 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 74 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (44% lower).
The record links to 1 condition, with Nonconvulsive Seizures appearing as the primary indexed condition, and to 2 interventions - of which fPHT is the first listed.
NCT01458522 lists 11 locations in 8 states (Massachusetts, North Carolina, California).
Frequently Asked Questions
What is clinical trial NCT01458522 about?
NCT01458522 is a clinical study titled "Intravenous Lacosamide Compared With Fosphenytoin in the Treatment of Patients With Frequent Nonconvulsive Seizures". This a phase 2 study comparing the efficacy of intravenous (IV) lacosamide (LCM) with IV fosphenytoin (fPHT) in controlling frequent nonconvulsive seizures (NCSs), the Adverse Events profile of LCM compared with fPHT when used to treat frequent NCSs, and length of stay in an intensive care unit for ...
What is the current status of trial NCT01458522?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 74 participants. The study started on 2012-05. Estimated completion is 2015-07.
What conditions does trial NCT01458522 study?
This clinical trial studies the following conditions: Nonconvulsive Seizures.
What interventions are being tested in trial NCT01458522?
The interventions under investigation include: fPHT (DRUG), LCM (DRUG).
Who is sponsoring clinical trial NCT01458522?
This trial is sponsored by Aatif Husain, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01458522 being conducted?
This trial has 11 study locations across California, Connecticut, Georgia, Massachusetts, North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Nonconvulsive Seizures
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT01458522's enrollment target sits among peer trials
74 920th of 2000 higher than 1,077 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT03422731 · 74 participants · Early Phase 1
Multi-modality Imaging and Collection of Biospecimen Samples in Understanding Bone Marrow Changes in Patients With Acute Myeloid Leukemia Undergoing TBI and Chemotherapy
- NCT03804853 · 74 participants · NA
Rehabilitation Following Reverse Total Shoulder Arthroplasty
- NCT04065776 · 74 participants · NA
Evaluation of Hippocampal-Avoidance Using Proton Therapy in Low-Grade Glioma
- NCT04771156 · 74 participants · Phase 4
Ketorolac in Palatoplasty
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia