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NCT01452074 · ClinicalTrials.gov registry record · NA
Progressive Metabolic Adaptations to Low Intensity Exercise Training and Weight Loss
A NA study, sponsored by University of Michigan.
- Completed
- Registry status
- NA
- Development phase
- 16
- Enrollment target
NCT01452074: Completed NA study, sponsored by University of Michigan.
NCT01452074 is a NA study that has completed, run by University of Michigan. The registered enrollment target is 16 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01452074, a NA study, has completed, sponsored by University of Michigan.
- COMPLETED
- Registry status
- NA
- Development phase
- 16 participants
- Enrollment target
Study Summary
the investigators first aim is to determine the effect of low intensity exercise (without weight loss) on insulin sensitivity, muscle lipid metabolism, and factors regulating these processes in skeletal muscle after 1 day, 2 wks, 12 wks of training, and again after 3 days without exercise in obese adults. the investigators second aim is to determine the effect of combining low intensity exercise training with 10% weight loss on insulin sensitivity, muscle lipid metabolism, and factors regulating these processes in skeletal muscle. Although a single 40 minute session of exercise at a low exercise intensity will not improve insulin sensitivity, the investigators anticipate adaptations after two weeks of exercise training (6 session/wk; 12 session total) will improve insulin sensitivity and be accompanied by a reduction in fatty acid intermediates and a reduction in markers for pro-inflammatory activation in muscle. the investigators anticipate changes in insulin sensitivity, fatty acid partitioning, and pro-inflammatory markers the day after the last session of a 12 wk training program (without weight-loss) will be similar to that measured after 2 weeks of training. the investigators anticipate insulin sensitivity, accumulation of fatty acid intermediates, and pro-inflammatory activation will be markedly improved after 10% weight loss when measured the day after exercise. the investigators would expect the improvements in Insulin sensitivity, accumulation of fatty acid intermediates, and markers of inflammatory stress will be significantly attenuated when measured 3 days after the most recent exercise session, but beneficial effects of 10% weight loss on these metabolic endpoints will persist when compared with before weight loss.
Primary Outcome
A hyperinsulinemic-euglycemic clamp will be used to assess peripheral insulin sensitivity
Interventions
- OTHER Exercise Training
- OTHER Weight Loss with continued Exercise Training
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 16 participants |
| Start Date | 2011-07 |
| Est. Completion | 2014-07-18 |
| Phase | NA |
What the finished NCT01452074 record still lists
NCT01452074 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 16 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 2 interventions - of which Exercise Training is the first listed.
NCT01452074 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01452074 about?
NCT01452074 is a clinical study titled "Progressive Metabolic Adaptations to Low Intensity Exercise Training and Weight Loss". the investigators first aim is to determine the effect of low intensity exercise (without weight loss) on insulin sensitivity, muscle lipid metabolism, and factors regulating these processes in skeletal muscle after 1 day, 2 wks, 12 wks of training, and again after 3 days without exercise in obese a...
What is the current status of trial NCT01452074?
This trial is currently completed. It is a NA study. The enrollment target is 16 participants. The study started on 2011-07. Estimated completion is 2014-07-18.
What interventions are being tested in trial NCT01452074?
The interventions under investigation include: Exercise Training (OTHER), Weight Loss with continued Exercise Training (OTHER).
Who is sponsoring clinical trial NCT01452074?
This trial is sponsored by University of Michigan, which has 1,327 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01452074's enrollment target sits among peer trials
16 1871st of 2000 higher than 120 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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