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NCT01452074 · ClinicalTrials.gov registry record · NA
Progressive Metabolic Adaptations to Low Intensity Exercise Training and Weight Loss
A NA study, sponsored by University of Michigan.
- Completed
- Registry status
- NA
- Development phase
- 16
- Enrollment target
NCT01452074 is a NA study that has completed, run by University of Michigan. The registered enrollment target is 16 participants.
The verdict
NCT01452074, a NA study, has completed, sponsored by University of Michigan.
- COMPLETED
- Registry status
- NA
- Development phase
- 16 participants
- Enrollment target
Study Summary
the investigators first aim is to determine the effect of low intensity exercise (without weight loss) on insulin sensitivity, muscle lipid metabolism, and factors regulating these processes in skeletal muscle after 1 day, 2 wks, 12 wks of training, and again after 3 days without exercise in obese adults. the investigators second aim is to determine the effect of combining low intensity exercise training with 10% weight loss on insulin sensitivity, muscle lipid metabolism, and factors regulating these processes in skeletal muscle. Although a single 40 minute session of exercise at a low exercise intensity will not improve insulin sensitivity, the investigators anticipate adaptations after two weeks of exercise training (6 session/wk; 12 session total) will improve insulin sensitivity and be accompanied by a reduction in fatty acid intermediates and a reduction in markers for pro-inflammatory activation in muscle. the investigators anticipate changes in insulin sensitivity, fatty acid partitioning, and pro-inflammatory markers the day after the last session of a 12 wk training program (without weight-loss) will be similar to that measured after 2 weeks of training. the investigators anticipate insulin sensitivity, accumulation of fatty acid intermediates, and pro-inflammatory activation will be markedly improved after 10% weight loss when measured the day after exercise. the investigators would expect the improvements in Insulin sensitivity, accumulation of fatty acid intermediates, and markers of inflammatory stress will be significantly attenuated when measured 3 days after the most recent exercise session, but beneficial effects of 10% weight loss on these metabolic endpoints will persist when compared with before weight loss.
Interventions
- OTHER Exercise Training
- OTHER Weight Loss with continued Exercise Training
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 16 participants |
| Start Date | 2011-07 |
| Est. Completion | 2014-07-18 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01452074
The ClinicalTrials.gov registry entry for NCT01452074 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 16 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Michigan, which has 1,327 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Exercise Training is the first listed.
NCT01452074 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT01452074 about?
NCT01452074 is a clinical study titled "Progressive Metabolic Adaptations to Low Intensity Exercise Training and Weight Loss". the investigators first aim is to determine the effect of low intensity exercise (without weight loss) on insulin sensitivity, muscle lipid metabolism, and factors regulating these processes in skeletal muscle after 1 day, 2 wks, 12 wks of training, and again after 3 days without exercise in obese a...
What is the current status of trial NCT01452074?
This trial is currently completed. It is a NA study. The enrollment target is 16 participants. The study started on 2011-07. Estimated completion is 2014-07-18.
What interventions are being tested in trial NCT01452074?
The interventions under investigation include: Exercise Training (OTHER), Weight Loss with continued Exercise Training (OTHER).
Who is sponsoring clinical trial NCT01452074?
This trial is sponsored by University of Michigan, which has 1,327 total clinical trials registered on ClinicalTrials.gov.
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