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NCT01447849 · ClinicalTrials.gov registry record · Phase 2
Lubiprostone and Mucus Secretion in Patients With Chronic Constipation
A Phase 2 study, sponsored by Texas Tech University Health Sciences Center, El Paso.
- Completed
- Registry status
- Phase 2
- Development phase
- 40
- Enrollment target
NCT01447849: Completed Phase 2 study, sponsored by Texas Tech University Health Sciences Center, El Paso.
NCT01447849 is a Phase 2 study that has completed, run by Texas Tech University Health Sciences Center, El Paso. The registered enrollment target is 40 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (70% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01447849, a Phase 2 study, has completed, sponsored by Texas Tech University Health Sciences Center, El Paso.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 40 participants
- Enrollment target
Study Summary
The investigators hypothesize that the symptoms of chronic constipation in some patients are developed due to diminished production and secretion of the alimentary tract mucus resulting in poor lubrication. Therefore, the investigators assume that administration of lubiprostone may restore this lubrication impairment by stimulation of mucus production and secretion within the gastrointestinal tract.
Primary Outcome
The rate of mucus and mucin secretion(mg/hr) will be measured in gastric juice aspirated in basal conditions and during stimulation with pentagastrin after 1 week of therapy with lubiprostone (Active Comparator) and compared with 1 week of placebo administration (Placebo Comparator).
Interventions
- DRUG placebo
- DRUG lubiprostone
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2011-08 |
| Est. Completion | 2012-11 |
| Phase | Phase 2 |
What the finished NCT01447849 record still lists
NCT01447849 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (70% lower).
The record links to 0 conditions, and to 2 interventions - of which placebo is the first listed.
NCT01447849 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01447849 about?
NCT01447849 is a clinical study titled "Lubiprostone and Mucus Secretion in Patients With Chronic Constipation". The investigators hypothesize that the symptoms of chronic constipation in some patients are developed due to diminished production and secretion of the alimentary tract mucus resulting in poor lubrication. Therefore, the investigators assume that administration of lubiprostone may restore this lub...
What is the current status of trial NCT01447849?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 40 participants. The study started on 2011-08. Estimated completion is 2012-11.
What interventions are being tested in trial NCT01447849?
The interventions under investigation include: placebo (DRUG), lubiprostone (DRUG).
Who is sponsoring clinical trial NCT01447849?
This trial is sponsored by Texas Tech University Health Sciences Center, El Paso, which has 35 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01447849's enrollment target sits among peer trials
40 1362nd of 2000 higher than 542 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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