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NCT01436773 · ClinicalTrials.gov registry record
Identification of Carotid Vasa Vasorum and Correlation With Acute Coronary Events
A clinical trial, sponsored by University of Pittsburgh.
- Completed
- Registry status
- 66
- Enrollment target
NCT01436773: Completed study, sponsored by University of Pittsburgh.
NCT01436773 is a clinical trial that has completed, run by University of Pittsburgh. The registered enrollment target is 66 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01436773 has completed, sponsored by University of Pittsburgh.
- COMPLETED
- Registry status
- 66 participants
- Enrollment target
Study Summary
Adventitial vasa vasorum (VV) as well as intraplaque microvessels are known to be associated with atherosclerotic plaque vulnerability. Contrast-enhanced ultrasound has been validated as a technique to measure the density of VV. Previous studies have demonstrated a relationship between identification of VV and relationship to vascular events such as stroke and myocardial infarction. No previous study has reported the utilization of contrast-enhanced ultrasound identification of VV in the carotid bed as a means of identifying patients at high risk for acute coronary events. Aims: In this study, the investigators will aim to identify VV and intraplaque microvessels along with carotid intima media thickness (CIMT), a known marker for acute coronary events. The investigators will attempt to measure the correlation of VV with acute coronary events independent of traditional cardiovascular disease (CVD) risk factors and CIMT. Methods: 90 volunteers (30 low risk patients, 30 patients with established coronary artery disease (CAD), and 30 patients with recent acute coronary syndrome (ACS)) will be enrolled. All patients will undergo contrast-enhanced ultrasound imaging of their carotid arteries and measurement of CIMT while obtaining baseline histories and assessment of traditional risk factors for coronary artery disease. VV density and CIMT will be measured in all patients. Statistical differences in VV among the three groups will be assessed and analyses will be made to attempt to identify if VV in the carotid bed is an independent predictor of acute coronary events after controlling for CIMT and traditional risk factors. Study population: The study population will reflect the patient population of UPMC. No individual will be excluded on the basis of race, gender, or ethnicity.
Primary Outcome
Assessed with ultrasound contrast agent, Definity, from Lantheus Medical Imaging.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 66 participants |
| Start Date | 2009-05 |
| Est. Completion | 2012-05 |
What the finished NCT01436773 record still lists
NCT01436773 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 66 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT01436773 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01436773 about?
NCT01436773 is a clinical study titled "Identification of Carotid Vasa Vasorum and Correlation With Acute Coronary Events". Adventitial vasa vasorum (VV) as well as intraplaque microvessels are known to be associated with atherosclerotic plaque vulnerability. Contrast-enhanced ultrasound has been validated as a technique to measure the density of VV. Previous studies have demonstrated a relationship between identificatio...
What is the current status of trial NCT01436773?
This trial is currently completed. The enrollment target is 66 participants. The study started on 2009-05. Estimated completion is 2012-05.
Who is sponsoring clinical trial NCT01436773?
This trial is sponsored by University of Pittsburgh, which has 1,238 total clinical trials registered on ClinicalTrials.gov.
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