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NCT01427855 · ClinicalTrials.gov registry record · NA
Dietary Protein Sources and Atherogenic Dyslipidemia
A NA study, sponsored by UCSF Benioff Children's Hospital Oakland.
- Completed
- Registry status
- NA
- Development phase
- 113
- Enrollment target
NCT01427855: Completed NA study, sponsored by UCSF Benioff Children's Hospital Oakland.
NCT01427855 is a NA study that has completed, run by UCSF Benioff Children's Hospital Oakland. The registered enrollment target is 113 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01427855, a NA study, has completed, sponsored by UCSF Benioff Children's Hospital Oakland.
- COMPLETED
- Registry status
- NA
- Development phase
- 113 participants
- Enrollment target
Study Summary
There is growing epidemiological evidence that consumption of red meat is associated with greater incidence of Cardiovascular Disease (CVD) than either white meat or non-meat foods. Research from our group has shown that a high saturated fat (SF) diet with a moderate red meat content selectively increases intermediate density lipoproteins (IDL) and larger low density lipoproteins (LDLs), which are more weakly associated with CVD risk than smaller LDLs. In contrast, the investigators have found that with a similar intake of SF, high beef consumption results in a preferential increase in small and medium LDL particles that are strongly related to CVD. To date, no studies have directly compared the lipoprotein effects of red meat with that of other food sources of protein in the context of both high and low saturated fat intake. The overall objective of this project is to test the hypothesis that the effects of SF on lipoprotein markers of CVD risk are influenced by sources of dietary protein. The investigators hypothesize that adverse effects of SF on plasma levels of LDL-cholesterol (C), apolipoprotein B (apo B), and atherogenic LDL particles are greater in a diet with a high content of red meat than in diets in which the major proteins are from white meat (poultry) or non-meat sources. The investigators propose a clinical trial in which 180 healthy men and women will be randomized to high SF or low SF diet groups, and within each group, consume diets with equivalent amounts of protein from red meat, white meat, and non-meat sources for 4 wks each in random order. Specifically, the investigators will test whether: (1) With high SF, the red meat diet, compared to the other protein sources, will result in higher levels of LDL-C, apoB, small and medium LDL, and total/high density lipoprotein (HDL)C; (2) With low SF, dietary protein source will not be related to any of these measurements; (3) With both the white meat and non-meat protein diets, increased LDL-C with high
Interventions
- OTHER High saturated fat red meat diet
- OTHER High saturated fat non-meat diet
- OTHER High saturated fat white meat diet
- OTHER Low saturated fat red meat diet
- OTHER Low saturated fat white meat diet
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 113 participants |
| Start Date | 2012-01 |
| Est. Completion | 2017-05 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01427855
The ClinicalTrials.gov registry entry for NCT01427855 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 113 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is UCSF Benioff Children's Hospital Oakland, which has 52 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 5 interventions - of which High saturated fat red meat diet is the first listed.
NCT01427855 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT01427855 about?
NCT01427855 is a clinical study titled "Dietary Protein Sources and Atherogenic Dyslipidemia". There is growing epidemiological evidence that consumption of red meat is associated with greater incidence of Cardiovascular Disease (CVD) than either white meat or non-meat foods. Research from our group has shown that a high saturated fat (SF) diet with a moderate red meat content selectively inc...
What is the current status of trial NCT01427855?
This trial is currently completed. It is a NA study. The enrollment target is 113 participants. The study started on 2012-01. Estimated completion is 2017-05.
What interventions are being tested in trial NCT01427855?
The interventions under investigation include: High saturated fat red meat diet (OTHER), High saturated fat non-meat diet (OTHER), High saturated fat white meat diet (OTHER), Low saturated fat red meat diet (OTHER), Low saturated fat white meat diet (OTHER).
Who is sponsoring clinical trial NCT01427855?
This trial is sponsored by UCSF Benioff Children's Hospital Oakland, which has 52 total clinical trials registered on ClinicalTrials.gov.
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