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NCT01415453 · ClinicalTrials.gov registry record · NA
Evoked Retinal Response
A NA study, sponsored by Columbia University.
- Terminated
- Registry status
- NA
- Development phase
- 1
- Enrollment target
NCT01415453: Clinical Trial NA study, sponsored by Columbia University.
NCT01415453 is a NA study that was terminated before completion, run by Columbia University. The registered enrollment target is 1 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01415453, a NA study, was terminated before completion, sponsored by Columbia University.
- TERMINATED
- Registry status
- NA
- Development phase
- 1 participants
- Enrollment target
Study Summary
Retinitis pigmentosa (RP) is the name given to a group of inherited eye diseases that affect the retina (the light-sensitive part of the eye). RP causes the breakdown of photoreceptor cells (cells in the retina that detect light). Photoreceptor cells capture and process light helping us to see. As these cells breakdown and die, people experience progressive vision loss. There is no known cure for retinitis pigmentosa. The investigators have observed that short pulses of focused ultrasound can cause perception of light when directed to spots on the retinal surface. The investigators propose to conduct a study to determine if pulsed ultrasound will stimulate the perception of light in the absence of functional photoreceptors in people with RP
Primary Outcome
The investigators will test the hypothesis that compression of retinal nerves by ultrasound force will cause perception of light (phosphenes) in blind subjects lacking functioning photoreceptors (retinitis pigmentosa). With each of two 5 msec ARFI exposures, if the subject either perceived the spark of light (phosphene), then it was documented as a positive response; if they did not, it was marked as a negative response.
Interventions
- PROCEDURE Ultrasound Stimulus
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1 participants |
| Start Date | 2011-07 |
| Est. Completion | 2012-06 |
| Phase | NA |
Why NCT01415453 stopped before completion
NCT01415453 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 1 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower).
The record links to 0 conditions, and to 1 intervention - of which Ultrasound Stimulus is the first listed.
NCT01415453 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01415453 about?
NCT01415453 is a clinical study titled "Evoked Retinal Response". Retinitis pigmentosa (RP) is the name given to a group of inherited eye diseases that affect the retina (the light-sensitive part of the eye). RP causes the breakdown of photoreceptor cells (cells in the retina that detect light). Photoreceptor cells capture and process light helping us to see. As t...
What is the current status of trial NCT01415453?
This trial is currently terminated. It is a NA study. The enrollment target is 1 participants. The study started on 2011-07. Estimated completion is 2012-06.
What interventions are being tested in trial NCT01415453?
The interventions under investigation include: Ultrasound Stimulus (PROCEDURE).
Who is sponsoring clinical trial NCT01415453?
This trial is sponsored by Columbia University, which has 958 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01415453's enrollment target sits among peer trials
1 2001st of 2000 the lowest of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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