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NCT01398943 · ClinicalTrials.gov registry record · NA
Nitric Oxide Bioavailability in Chronic Obstructive Pulmonary Disease (COPD)
A NA study, sponsored by Augusta University.
- Completed
- Registry status
- NA
- Development phase
- 60
- Enrollment target
NCT01398943: Completed NA study, sponsored by Augusta University.
NCT01398943 is a NA study that has completed, run by Augusta University. The registered enrollment target is 60 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01398943, a NA study, has completed, sponsored by Augusta University.
- COMPLETED
- Registry status
- NA
- Development phase
- 60 participants
- Enrollment target
Study Summary
More patients with chronic obstructive pulmonary disease (COPD) die from cardiovascular disease than direct pulmonary complications. Inflammation and oxidative stress, characteristic in COPD, are likely contributors to the reduction in nitric oxide (NO) bioavailability and vascular endothelial dysfunction in COPD patients; however, this has yet to be determined. Thus, the overall objective of this proposal is to identify the role of NO bioavailability in contributing to vascular endothelial dysfunction in patients with COPD and to provide insight into the molecular mechanisms involved. Our central hypothesis is that inflammation and oxidative stress, both independently, contribute to the reduction in NO bioavailability and vascular endothelial dysfunction in patients with COPD.
Primary Outcome
Brachial artery FMD induced by reactive hyperemia will be used to assess vascular endothelial function at baseline and several hours after each experimental intervention.
Interventions
- DRUG Tetrahydrobiopterin (BH4)
- DIETARY_SUPPLEMENT Antioxidant Cocktail
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2010-09 |
| Est. Completion | 2015-06 |
| Phase | NA |
What the finished NCT01398943 record still lists
NCT01398943 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower).
The record links to 0 conditions, and to 2 interventions - of which Tetrahydrobiopterin (BH4) is the first listed.
NCT01398943 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01398943 about?
NCT01398943 is a clinical study titled "Nitric Oxide Bioavailability in Chronic Obstructive Pulmonary Disease (COPD)". More patients with chronic obstructive pulmonary disease (COPD) die from cardiovascular disease than direct pulmonary complications. Inflammation and oxidative stress, characteristic in COPD, are likely contributors to the reduction in nitric oxide (NO) bioavailability and vascular endothelial dysfu...
What is the current status of trial NCT01398943?
This trial is currently completed. It is a NA study. The enrollment target is 60 participants. The study started on 2010-09. Estimated completion is 2015-06.
What interventions are being tested in trial NCT01398943?
The interventions under investigation include: Tetrahydrobiopterin (BH4) (DRUG), Antioxidant Cocktail (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT01398943?
This trial is sponsored by Augusta University, which has 106 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01398943's enrollment target sits among peer trials
60 1164th of 2000 higher than 745 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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