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NCT01398280 · ClinicalTrials.gov registry record · Early Phase 1
Effects of Aminocaproic Acid (ACA) on Rosacea-specific Inflammation
A Early Phase 1 study, sponsored by University of California, San Diego.
- Completed
- Registry status
- Early Phase 1
- Development phase
- 15
- Enrollment target
NCT01398280: Completed Early Phase 1 study, sponsored by University of California, San Diego.
NCT01398280 is a Early Phase 1 study that has completed, run by University of California, San Diego. The registered enrollment target is 15 participants, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (72% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01398280, a Early Phase 1 study, has completed, sponsored by University of California, San Diego.
- COMPLETED
- Registry status
- Early Phase 1
- Development phase
- 15 participants
- Enrollment target
Study Summary
The purpose of this study is to determine the effect of topical aminocaproic acid on the immune system by assessing the levels of antimicrobial peptides in the skin of patients with rosacea. It is hypothesized that aminocaproic acid applied topically will alter the body's immune system in patients with rosacea by inhibiting activation of antimicrobial peptides.
Primary Outcome
Serine protease activity of KLK5 in adult skin from patients with rosacea is measured after treatment with vehicle or aminocaproic acid cream. Protease activity of facial skin surface is monitored using a synthetic fluorogenic trypsin-like proteinase substrate. Protease activity is monitored as an increase of fluorescence (RFU/uL) with SpectraMax GEMINI EM.
Interventions
- DRUG Vehicle cream
- DRUG Topical aminocaproic acid (ACA) mixed with Vanicream
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2011-07 |
| Est. Completion | 2012-12 |
| Phase | Early Phase 1 |
What the finished NCT01398280 record still lists
NCT01398280 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 15 participants, a relatively small participant target, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (72% lower).
The record links to 0 conditions, and to 2 interventions - of which Vehicle cream is the first listed.
NCT01398280 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01398280 about?
NCT01398280 is a clinical study titled "Effects of Aminocaproic Acid (ACA) on Rosacea-specific Inflammation". The purpose of this study is to determine the effect of topical aminocaproic acid on the immune system by assessing the levels of antimicrobial peptides in the skin of patients with rosacea. It is hypothesized that aminocaproic acid applied topically will alter the body's immune system in patients w...
What is the current status of trial NCT01398280?
This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 15 participants. The study started on 2011-07. Estimated completion is 2012-12.
What interventions are being tested in trial NCT01398280?
The interventions under investigation include: Vehicle cream (DRUG), Topical aminocaproic acid (ACA) mixed with Vanicream (DRUG).
Who is sponsoring clinical trial NCT01398280?
This trial is sponsored by University of California, San Diego, which has 775 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01398280's enrollment target sits among peer trials
15 1403rd of 2000 higher than 527 of 2,000 other Early Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Early Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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