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NCT01395277 · ClinicalTrials.gov registry record · NA
Role of Flavanols In Cardiovascular Function in Healthy Aging
A NA study, sponsored by University of Texas at Austin.
- Completed
- Registry status
- NA
- Development phase
- 30
- Enrollment target
NCT01395277 is a NA study that has completed, run by University of Texas at Austin. The registered enrollment target is 30 participants.
The verdict
NCT01395277, a NA study, has completed, sponsored by University of Texas at Austin.
- COMPLETED
- Registry status
- NA
- Development phase
- 30 participants
- Enrollment target
Study Summary
Groups of naturally occurring compounds called flavonoids are found in foods such as fruits and vegetables, red wine, tea, dark chocolate and cocoa products. Diets rich in flavonoids are associated with decreased risk for cardiovascular disease and major cardiovascular events (i.e. myocardial infarction) and have been shown to improve blood pressure, insulin sensitivity, and vascular function in a variety populations (Type II diabetes, elderly, smokers, etc.). The presumed beneficial effects of these compounds are thought to act through their inherent ability to scavenge free radicals. Specifically flavonoids scavenge superoxide anions which are free radicals that react with nitric oxide (NO) to produce peroxynitrite. The formation of peroxynitrite ultimately reduces the bioavailability of NO which is essential for vasodilation and thus vascular health and function. Normal aging is associated with impaired endothelial function, which presumably is due to less than optimal levels of NO bioavailability. Therefore, interventions that can increase NO bioavailability would be expected to improve microvascular function and vascular health in this population. The purpose of this study is to investigate the effects of dietary flavonoid supplementation on the vasodilatory capacity of the cutaneous vasculature, as well as on cerebral vascular reactivity and arterial stiffness in young and old humans. This study will test the hypothesis that acute dietary flavonoid treatment will improve impaired cutaneous vasodilatory capacity, cerebral vasomotor reactivity, and reduce arterial stiffness in older but not young humans.
Interventions
- DIETARY_SUPPLEMENT High Flavanol first then Low Flavanol
- DIETARY_SUPPLEMENT Low Flavanol first then High Flavanol
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2011-09 |
| Est. Completion | 2014-05 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01395277
The ClinicalTrials.gov registry entry for NCT01395277 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 30 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Texas at Austin, which has 257 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which High Flavanol first then Low Flavanol is the first listed.
NCT01395277 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT01395277 about?
NCT01395277 is a clinical study titled "Role of Flavanols In Cardiovascular Function in Healthy Aging". Groups of naturally occurring compounds called flavonoids are found in foods such as fruits and vegetables, red wine, tea, dark chocolate and cocoa products. Diets rich in flavonoids are associated with decreased risk for cardiovascular disease and major cardiovascular events (i.e. myocardial infarc...
What is the current status of trial NCT01395277?
This trial is currently completed. It is a NA study. The enrollment target is 30 participants. The study started on 2011-09. Estimated completion is 2014-05.
What interventions are being tested in trial NCT01395277?
The interventions under investigation include: High Flavanol first then Low Flavanol (DIETARY_SUPPLEMENT), Low Flavanol first then High Flavanol (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT01395277?
This trial is sponsored by University of Texas at Austin, which has 257 total clinical trials registered on ClinicalTrials.gov.
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